三物白散整体水平抗肿瘤免疫正相调节效应研究

目的在整体水平上研究三物白散抗肿瘤过程中免疫正相调节效应。方法建立小鼠腋下移植性肿瘤模型,三物白散设大、中、小3个剂量组,另设1个正常对照组(生理盐水组)和一个阳性药组(5-氟尿嘧啶组),用药8 d后,摘取皮下瘤块、胸腺、脾脏,称其质量,计算抑瘤率、脾脏指数、胸腺指数,另摘眼球采血取血清,用放射免疫检测法检测荷瘤鼠血清中IL-2I、L-4表达。结果与正常对照组相比,用药组的体内抑瘤率均有显著差异(P<0.01);三物白散各组的胸腺、脾脏质量与正常对照组无明显差异,5-Fu组胸腺、脾脏质量与正常对照组相比差异显著(P<0.05);与正常对照组相比,三物白散各剂量组IL-2水平升高(P<0.01),IL-4水平下降(P<0.05)。结论三物白散在整体水平上具有确切的抗肿瘤免疫正相调节作用。 

Normal Phase Immunity- Regulating Effect of Sanwubai Powder in Treating Tumor

OBJECTIVE To investigate into the normal phase immunity-regulating effect of Sanwubai Powder in treating tumor.METHOD Subaxillary transplantation tumor models were made,treated with Sanwubai Powder in three different dosages,compared with a normal control group(saline group) and a positive medicine group (5-fluorouracil group).Eight days after drug administration,the tumors,thymus and spleen were taken and weighed and other indexes calculated.RESULT The tumor-inhibiting rates in the groups treated with medications were markedly different from those in the normal control group(P<0.01);no difference was found between the weights of thymus and spleen in the groups treated with Sanwubai Powder and the control group;in the 5-fluorouracil group,the weight of the spleen was markedly different from that in the control group(P<0.05);compared with the normal control group,IL-2 level rose(P<0.01) and IL-4 level dropped in the groups treated with Sanwubai Powder.CONCLUSION Sanwubai Powder has overall immunity-regulating effect in the treatment of tumor.