Influenza A modification of endotoxin-induced otitis media with effusion in the guinea pig |
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Authors: | Y Ohashi Y Nakai Y Ohno Y Sugiura H Okamoto H Sakamoto M Hayashi |
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Institution: | (1) Department of Otolaryngology, Osaka City University Medical School, 1-5-7 Asahimachi, 545 Abeno, Osaka, Japan |
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Abstract: | Summary A total of 120 Hartley strain guinea pigs were used to investigate the possible role of influenza A in endotoxin-induced otitis media with effusion. Intratympanic inoculation of 0.2 ml physiologic saline solution containing 104 plaque-forming units (PFU)/ml of influenza A suspension or 100 ng/ml lipopolysaccharide failed to induce either middle ear effusions or mucociliary pathologies in the tubotymapanum. In contrast, intratympanic inoculation 100 ng/ml endotoxin resulted in prolonged mucociliary dysfunction and middle ear effusions when 0.2 ml 104 PFU/ml of influenza A was inoculated in the tympanic cavity. The inference is drawn that an influenza A infection might predispose the middle ear to endotoxin-induced otitis media with effusion.This paper was presented in part at the Fifth International Symposium on Recent Advances in Otitis Media in Ft. Lauderdale, Florida, USA, on 20–24 May 1991 |
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Keywords: | Otitis media with effusion Influenza A virus Endotoxin Mucociliary dysfunction |
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