| 11C—甲硫氨酸PET在乳腺癌诊疗中的价值 |
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| 引用本文： | 徐志英,李善春. 11C—甲硫氨酸PET在乳腺癌诊疗中的价值[J]. 国际放射医学核医学杂志, 2008, 32(5) |
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| 作者姓名： | 徐志英 李善春 |
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| 作者单位： | 烟台市毓璜项医院核医学科,264000 |
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| 摘 要： | 乳腺癌是我国妇女最常见的恶性肿瘤之一,也是妇女中除肺癌外病死率最高的恶性肿瘤,早期诊断是降低乳腺癌病死率的关键因素.目前,乳腺癌的诊断方法主要是钼靶X线乳腺摄影、超声检查、磁共振成像、细针穿刺活组织检查等.乳腺癌的基因变化导致癌肿血流增加,葡萄糖代谢、氨基酸转运、蛋白质合成、受体表达增加,DNA合成和细胞增殖活跃,并诱导细胞凋亡.PET结果显示.肿瘤部位对18F-氟脱氧葡萄糖(18F-FDG)和11C-甲硫氨酸(11C-MET)摄取均增高而11C-MET合成方便快捷,价格较18F-FDG低,其在乳腺癌中的应用价值国外已有诸多报道.
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| 关 键 词： | 乳腺肿瘤 体层摄影术,发射型计算机 11C-甲硫氨酸 |
The clinical and diagnostic value of 11C-methionine PET in breast cancer |
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| XU Zhi-ying,LI Shan-chun. The clinical and diagnostic value of 11C-methionine PET in breast cancer[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2008, 32(5) |
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| Authors: | XU Zhi-ying LI Shan-chun |
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| Abstract: | Breast cancer is one of the most ordinary malignant tumors in woman, and its mortality is only less than that of lung cancer. Early diagnosis is a key to reducing the mortality rate. The commonly used methods to diagnose breast cancer include mammography, ultrasonography, magnetic resonance imaging.Genetic changes of breast cancer comprise increased tumor blood flow, increased levels of glucose metabolism, amino acid transport, protein synthesis receptor expression, enhanced DNA synthesis and cell proliferation, and induction of apoptosis. It shows high 18F-fluoredeoxyglucose(18F-FDG) or methionine uptake in breast cancer, 11C-methionine (11C-MET) has a lower price. PET with 11C-MET has a high prognostic value in breast cancer. |
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| Keywords: | Breast neoplasms Tomography,emission-computed 11C-methionine |
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