Acute changes in the renin-angiotensin-aldosterone system, catecholamines and prostaglandins during captopril in man |
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| Authors: | P Lijnen L J Verschueren R Fagard J Staessen A Amery |
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| Institution: | Department of Pathophysiology, University of Leuven, Belgium. |
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| Abstract: | The acute hypotensive effect of 25 mg captopril was investigated in 26 hypertensive patients (11 essential and 15 with renal arterial disease). Intra-arterial blood pressure was recorded continuously and arterial blood was sampled for renin, angiotensin I and II, aldosterone, kininase II, catecholamines and prostaglandins. Captopril provoked increases in plasma renin activity, active and total plasma renin concentration and angiotensin I; decreases in plasma kininase II activity, angiotensin II, aldosterone, prostaglandins E2 and F2 alpha and no changes in plasma (nor)adrenaline, dopamine and inactive renin concentration. |
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