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| 组织工程角膜片移植治疗无菌性角膜溃疡的实验研究 | |
| 引用本文： | 张超,胡丹,刘源,雷娟,金岩. 组织工程角膜片移植治疗无菌性角膜溃疡的实验研究[J]. 眼科新进展, 2006, 26(3): 176-179 |
| 作者姓名： | 张超 胡丹 刘源 雷娟 金岩 |
| 作者单位： | 1. 710054,陕西省西安市,武警陕西总队医院眼科 2. 710032,陕西省西安市,第四军医大学西京医院眼科 3. 第四军医大学口腔医学院口腔组织病理学教研室,组织工程研发中心 |
| 摘 要： | 目的探讨组织工程角膜片治疗角膜溃疡的可行性及疗效。方法将16只新西兰大白兔制作成角膜溃疡模型,随机分为2组,每组8只,分别作单纯羊膜移植和以羊膜为载体的组织工程角膜片移植。术后进行大体观察、裂隙灯观察、组织学观察、扫描电镜观察。结果羊膜为载体组织工程角膜片移植治疗角膜溃疡,平均7.5周溃疡完全愈合,角膜恢复透明性和屈光性,较单纯羊膜移植组(平均9周)角膜溃疡修复快,效果好结论羊膜为载体构建的组织工程角膜片可以有效治疗角膜溃疡。 |
| 关 键 词： | 组织工程 角膜溃疡 移植 羊膜 |
| 文章编号： | 1003-5141(2006)03-0176-04 |
| 收稿时间： | 2005-12-15 |
| 修稿时间： | 2006-01-09 |
Experimental study on tissue engineering cornea transplantation for corneal ulcer |
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| ZHANG Chao,HU Dan,LIU Yuan,LEI Juan,JIN Yan. Experimental study on tissue engineering cornea transplantation for corneal ulcer[J]. Recent Advances in Ophthalmology, 2006, 26(3): 176-179 | |
| Authors: | ZHANG Chao HU Dan LIU Yuan LEI Juan JIN Yan |
| Abstract: | Objective To approach the feasibility and curative affect of tissue engineered corneas for corneal ulcer.Methods A total of 16 rabbit corneal ulcer models were prepared by chitosan membrane transplantation.All animals were divided randomly into two groups and tranplanted respectively with amniotic membrane and tissue engineered corneas which composed of living rabbit corneal stroma cells and amniotic membrane.The recovery of cornea were investigated through clinical observation,slit lamp observation,histological observation and scanning electron microscope observation.Results The tissue engineered cornea cured corneal ulcer after transplantation.The average healing time for tissue engineered corneal group and amniotic membrane group are respectively 7.5 weeks and 9 weeks after operation.Compared with amniotic membrane group,tissue engineered corneal group were healed more effected,finally cornea became transparent again.Conclusion Tissue engineered corneas which compose of living rabbit corneal stroma cells and amniotic membrane can treat corneal ulcer effectively. |
| Keywords: | tissue engineering corneal ulcer transplantation amniotic membrane |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |