| Shh和Ptch在食管鳞状细胞癌中的表达研究 |
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| 引用本文： | 王树俊,张剑,裘宋良,杨观瑞,张亚冰,裘一兵,张聚真,孙豫,杨静,薛乐勋,赵立群. Shh和Ptch在食管鳞状细胞癌中的表达研究[J]. 肿瘤基础与临床, 2006, 19(3): 172-174 |
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| 作者姓名： | 王树俊 张剑 裘宋良 杨观瑞 张亚冰 裘一兵 张聚真 孙豫 杨静 薛乐勋 赵立群 |
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| 作者单位： | 1. 河南省医学科学研究所
2. 郑州大学细胞生物学研究室,河南,郑州,450052 |
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| 基金项目： | 教育部"211"工程建设项目 |
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| 摘 要： | 目的探讨食管鳞状细胞癌中Shh和Ptch的表达及其意义。方法应用免疫组织化学方法检测35例食管癌及癌旁组织中shh和Ptch的表达情况。结果食管鳞癌中Shh和Ptch的表达阳性率分别为74．3％和68．6％，与正常组织相比Shh和Ptch在食管鳞癌组织中高表达。结论Shh和Ptch的高表达及Hh通路的激活参与了食管鳞癌的发生，可能足食管癌治疗的一个理想靶标。
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| 关 键 词： | 食管鳞状细胞癌 免疫组化 |
| 文章编号： | 1673-5412（2006）03-0172-03 |
| 收稿时间： | 2006-02-28 |
| 修稿时间： | 2006-02-28 |
A Study of Shh and Ptch Expressions in Esophageal Squamous Cell Carcinoma |
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| Wang Shujun,Zhang Jian,Qiu Songliang,Yang Guanrui,Zhang Yabing,Qiu Yibing,Zhang Juzhen,Sun Yu,Yang Jing,Xue Lexun,Zhao Liqun. A Study of Shh and Ptch Expressions in Esophageal Squamous Cell Carcinoma[J]. journal of basic and clinical oncology, 2006, 19(3): 172-174 |
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| Authors: | Wang Shujun Zhang Jian Qiu Songliang Yang Guanrui Zhang Yabing Qiu Yibing Zhang Juzhen Sun Yu Yang Jing Xue Lexun Zhao Liqun |
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| Affiliation: | 1. Department of Tumor Pathology, Henan Institute of Medical Science ; 2. Laboratory of Cell Biology, Zhengzhou University, Zhengzhou 450052, China |
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| Abstract: | Objective To determine the expression status of Shh and Ptch genes in esophageal squamous cell carcinoma(ESCC).Methods The expressions of Shh and Ptch genes were evaluated by immunohistochemistry in 35 cases with ESCC along with their corresponding adjacent benign tissues.Results The positive expression rates of Shh and Ptch in ESCC were 74.3% and 68.6% respectively.The expressions of Shh and Ptch in ESCC were elevated compared with their corresponding adjacent benign tissues.Conclusions The elevated expressions of Shh and Ptch and the activation of Hh signaling pathway participated in the generation of ESCC.They may be ideal targets for therapy against ESCC. |
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| Keywords: | Shh Ptch |
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