Human cytomegalovirus polypeptides stimulate neutralizing antibody in vivo |
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| Authors: | L Rasmussen J Mullenax M Nelson T C Merigan |
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| Affiliation: | Division of Infectious Diseases, Stanford University School of Medicine, Stanford, California 94305, USA |
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| Abstract: | At least three human cytomegalovirus polypeptides are targets for virus neutralizing antibody; a single protein of 86,000 molecular weight (p86) and two coimmunoprecipitating proteins of 130,000 and 55,000 molecular weight (p130/55). These polypeptides have been isolated by immunoaffinity chromatography and tested for immunogenicity in guinea pigs. Neutralizing antibody was detected after immunization with both p86 and p130/55. Hyperimmune sera to p130/55, but not p86, were dependent upon guinea pig complement for virus neutralization. |
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| Keywords: | Author to whom requests for reprints should be addressed. |
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