血管内皮生长因子受体KDR在髓母细胞瘤中的表达及临床意义

目的　探索激酶插入嵌合受体 /胎肝激酶 - 1(kinase insert domain- containing receptor/ fetal liverkinase- 1,KDR/ Flk- 1)在髓母细胞瘤中的表达情况及其与预后的关系。方法　通过免疫组化方法测定 KDR在 5 0例髓母细胞瘤和 10例正常小脑组织中的表达 ,并结合临床资料 ,对病人生存时间与 KDR表达阳性率之间的关系进行分析。结果　 1正常小脑组织标本极少表达 KDR,而髓母细胞瘤标本多为不同程度的阳性表达 ,且以高阳性率为主 ,并发现阳性染色主要位于肿瘤细胞浆 ,部分内皮细胞中度或轻微着色。 2生存时间长者 KDR表达阳性率较低 (r=- 0 .5 2 7,P<0 .0 1)。结论　 KDR不仅在髓母细胞瘤血管内皮细胞中有表达 ,在肿瘤细胞中也有表达 ;KDR在肿瘤细胞中的阳性表达率与髓母细胞瘤的预后呈负相关。髓母细胞瘤中 KDR的表达水平可以作为判断病人预后的指标之一。

Expression of KDR in Medulloblastoma and Its Clinical Implication Cheng Hongwei*, Mao Boyong, Zhang Shangfu,Cheng Niang. *Department of Neurosurgery, The First Affiliated Hospital, WCUMS, Chengdu 610041, China

Objective To gain an insight into the possible relationship between the expression of kinase insert domain containning receptor(KDR) and the prognosis of medulloblastoma. Methods Fifty cases of medulloblastoma of the posterior fossa and ten cases of normal cerebellar tissue were studied via a combination of immunnohistochemical staining in formalin fixed paraffin embedded sections. Results KDR was expressed weakly in 1 of 10 normal cerebellar tissues, while KDR was either moderately or strongly expressed in most of the medulloblastomas(49 of 50 cases).Moreover, KDR was expressed not only in the endothelial cells of tumor vasculature, but also in tumor cells.Correlation analysis indicated that expression of KDR was correlated significantly with survival time(r=-0.527, P <0.01).Conclusion KDR was expressed in most of the medulloblastomas, not only in the endothelial cells of tumor vasculature,but also in tumor cells.The expression level of KDR had a negative correlation with the survival time, thus it might be used as one of the prognosticators of medulloblastoma.