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Sequence determination of a quadripartite dsRNA virus isolated from Aspergillus foetidus |
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| Authors: | Zisis Kozlakidis Noemi Herrero Selin Ozkan Lakkhana Kanhayuwa Atif Jamal Muhammad F. Bhatti Robert H. A. Coutts |
| Affiliation: | 1. Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, Sir Alexander Fleming Building, Imperial College Road, London, SW7 2AZ, UK 2. The Department of Infectious Diseases, King’s College, London, SE1 9RT, UK 3. Fondazione Edmund Mach, IASMA Research and Innovation Centre, Via Mach 1, San Michele all’ Adige, 38010, TN, Italy 4. National Agricultural Research Centre, Park Road, Islamabad, 45500, Pakistan 5. Atta-ur-Rehman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Sector H-12, Kasmir Highway, Islamabad, 44000, Pakistan |
| Abstract: | Virus infection of Aspergillus foetidus was documented over 40 years ago and was one of the first mycovirus infections described in a filamentous fungus. The virus, named Aspergillus foetidus virus (AfV), contains at least two types of icosahedral particles, called AfV-fast (-F) and AfV-slow (-S) virions, based on their relative electrophoretic mobilities. Here, we report the complete nucleotide sequence of the AfV-F genome isolated from virions purified from the prototype isolate of the fungus. The AfV-F double-stranded (ds) RNA genome is tetra-segmented, and the plus strands of each of the four segments, but not the minus strands, are polyadenylated. The organisation and sequences of the four AfV-F dsRNAs are similar to those described for Alternaria alternata virus 1, which we propose is a member of an emerging mycovirus genus (“Alternavirus”) and family (“Alternaviridae”), which also includes AfV-F. |
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