| 电离辐射对小鼠淋巴结皮质细胞凋亡的影响 |
| |
| 引用本文： | 陈东,刘树铮,刘佳梅. 电离辐射对小鼠淋巴结皮质细胞凋亡的影响[J]. 吉林大学学报(医学版), 1999, 25(3): 223-225 |
| |
| 作者姓名： | 陈东 刘树铮 刘佳梅 |
| |
| 作者单位： | 1. 基础医学院组胚教研室,长春,130021
2. 卫生部放射生物学重点实验室 |
| |
| 基金项目： | 教育部留学回国人员科研启动基金;; |
| |
| 摘 要： | 目的：研究不同剂量Ｘ射线全身照射对小鼠淋巴结皮质细胞凋亡的影响。方法：采用原位末端标记（ＴＵＮＥＬ）法检测高、低剂量电离辐射后肠系膜淋巴结皮质中细胞凋亡情况。结果：淋巴结皮质的不同区域对高、低剂量电离辐射的敏感性均不同。结论：低剂量辐射所致的小结间区及深皮质区凋亡细胞数减少，是低水平辐射兴奋效应的一种表现。
|
| 关 键 词： | 电离辐射 淋巴结 细胞凋亡 原位末端标记 |
| 修稿时间： | 1998-10-16 |
Effect of ionizing radiation on apoptosis in the cortex of mouse lymph node |
| |
| Chen Dong,Liu Shuzheng,Liu Jiamei. Effect of ionizing radiation on apoptosis in the cortex of mouse lymph node[J]. Journal of Jilin University: Med Ed, 1999, 25(3): 223-225 |
| |
| Authors: | Chen Dong Liu Shuzheng Liu Jiamei |
| |
| Affiliation: | Chen Dong1,Liu Shuzheng2,Liu Jiamei1 |
| |
| Abstract: | Objective:To study the alteration of apoptosis in the cortex of mouse lymph node following whole body Xirradiation.Methods:The method of TdTmediated dUTP nick end labeling (TUNEL) was used to detect apoptosis the cortex of mouse lymph node.Results:The sensitivity to high and low dose ionizing radiation was distinct in different area of the cortex.Conclusion:The decrease of apoptotic cells in the internodular and deep cortex indicate that low dose radiation may suppress the apoptosis of T lymphocytes and play a role in immune regulation. |
| |
| Keywords: | ionizing radiation lymph node apoptosis TUNEL (TdTmediated dUTP nick end labeling) |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
