| 谷胱甘肽转移酶T1基因型与苯中毒遗传易感性 |
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| 引用本文： | 陈艳,吴春玲,戴宇飞,邢彩虹,李桂兰. 谷胱甘肽转移酶T1基因型与苯中毒遗传易感性[J]. 毒理学杂志, 2002, 16(4): 216-218 |
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| 作者姓名： | 陈艳 吴春玲 戴宇飞 邢彩虹 李桂兰 |
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| 作者单位： | 中国疾病预防控制中心职业卫生与中毒控制所 北京100050(陈艳，吴春玲，戴宇飞，邢彩虹)，中国疾病预防控制中心职业卫生与中毒控制所 北京100050(李桂兰) |
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| 基金项目： | 国家自然科学基金资助 (39870 85) |
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| 摘 要： | 目的 探讨谷胱甘肽转移酶T1(GSTT1)基因多态与苯中毒遗传易感性的关系。方法 应用聚合酶链式反应 (PCR)方法对 3 5例苯中毒病例、44例苯作业工人及 2 6例正常对照组的GSTT1的基因型进行了检测。结果 苯中毒患者组GSTT1缺失基因型频率为 60 % ,明显高于正常对照组的 46 15 %和苯作业工人组的 40 91% ,但未出现统计学意义(P >0 0 5 )。结论 GSTT1基因多态与苯中毒遗传易感性无关。但由于例数不多 ,这一结果有待于进一步研究证实
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| 关 键 词： | 苯中毒 GSTT1 基因多态 遗传易感性 聚合酶链反应 谷胱甘肽转移酶T1基因型 |
| 文章编号： | 1002-3127(2002)04-0216-03 |
| 修稿时间： | 2002-06-06 |
Glutathione S-transferase T1 genotype and susceptibility to benzene poisoning |
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| CHEN Yan,WU Chun|ling,DAI Yu|fei,et al.. Glutathione S-transferase T1 genotype and susceptibility to benzene poisoning[J]. Journal of Toxicology, 2002, 16(4): 216-218 |
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| Authors: | CHEN Yan WU Chun|ling DAI Yu|fei et al. |
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| Abstract: | Objective To investigate the relationship between genetic polymorphism of glutathione S|transferase T1(GSTT1) and susceptibility to benzene poisoning. Methods GSTT1 genotype for 35 patients with benzene poisoning and 44 workers exposed to benzene and 26 healthy control were detected by polymerase chain reaction (PCR).Results The frequency of GSTT1 null genotype was 60% in patients with benzene poisoning,which was higher than workers exposed to benzene(46^15%) and control(40^91%).But there were no significant differences in statistic analysis.Conclusion Genetic polymorphism of GSTT1 and susceptibility to benzene poisoning were indifferences.But the conclusion should be further identified because the result was based on small numbers. |
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| Keywords: | Benzene poisoning Glutathione S|transferase T1 Genetic polymorphism Genetic susceptibility |
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