VEGF在三阴性乳腺癌中的表达及意义

【目的】探讨血管内皮生长因子（VEGF）在三阴性乳腺癌（TNBC）中的表达及意义。【方法】采用SP免疫组织化学法检测 VEGF蛋白在50例 TNBC组织石蜡标本（TNBC组）和50例非三阴性乳腺癌组织石蜡标本（非TNBC组）中的表达，并分析其与 TNBC临床病理因素的关系及对预后的影响。【结果】TNBC组VEGF阳性表达率50．0％（25/50）显著高于非TNBC组阳性表达率（30．0％，15/50），其差异有统计学意义（χ2＝4．92，P＜0．05）；VEGF在 TNBC 组织中的表达与腋窝淋巴结转移、脉管内有癌栓密切相关（P ＜0．05）；TNBC组 VEGF阳性表达组的5年无病生存率（DFS）和5年总生存率（OS）分别为16．0％（4/25）和76．0％（19/25），阴性表达组的5年无病生存率和5年总生存率分别为48．0％（12/25）和96．0％（24/25），两组比较有统计学意义（P＜0．05）。【结论】VEGF在 TNBC发生发展过程中，具有提高肿瘤细胞殖能力和转移潜力的作用，且其表达异常增高者可能预后不良。

Expression and Significance of VEGF in Triple Negative Breast Cancer

Objective]To explore the expression and significance of VEGF in triple negative breast cancer （TNBC）.Methods]SP immunohistochemical method was used to detect the expression of VEGF in paraffin specimens from 50 cases of TNBC（TNBC group）and 50 cases of non-TNBC（non-TNBC group）.The relation-ship between VEGF and clinical pathological factors of TNBC and the effect of VEGF on the prognosis were analyzed.Results]The positive expression rate of VEGF in TNBC was 50.0%（25/50）which was markedly higher than that in non-TNBC group（30.0%,15/50）,and there was significant difference between two groups（χ2=4.92,P〈0.05）.The expression of VEGF in TNBC tissues was closely associated with axillary lymph node metastasis and cancer embolus in vessels（P〈0.05）.The 5-year disease-free survival（DFS）and overall survival（OS）of patients with VEGF positive expression in TNBC group were 16.0%（4/25）and 76.6%（19/25）respectively,and those of patients with VEGF negative expression in TNBC group were 48.0%（12/25）and 96.0%（24/25）respectively,and there was significant difference between two groups（P〈0.05）.Conclusion]VEGF plays an important role in the occurrence and development of TNBC.VEGF can improve the proliferation ability and metastasis potentials of tumor cells.The abnormal increasing of VEGF expression may predict the poor prognosis.