血流控制下时间门的人体血糖无创实验测量

目的 为了进一步提高人体血糖无创伤测量的精度,从而达到临床的要求,对本课题组提出的人体血糖无创伤测量的新方法进行实验测量.方法 在利用压力停止受测部分血流条件下,采用时间相关单光子计数技术测量双波长光入射下透射光谱的动态分布.对3例人体进行了口服葡萄糖耐量试验（OGTT）,用拉普拉斯变换选取早期到达的光子,同时用罗氏血糖仪对人体血糖浓度进行读数.结果 当拉普拉斯参数取1Gs^-1时,实验测得的参数斜率（PS）随人体血糖浓度变化曲线的拟合度最好（决定系数R^2=0.0922）.结论 实验测量结果显示,选取合适的拉普拉斯参数可以得到更好的测量准确性,基于血流控制下的时间门技术用于无创伤测量人体血糖浓度是可行的.

Noninvasive measurement of human blood glucose under flow control of time gate

Objective In order to further improve the noninvasive measurement precision of human blood glucose and achieve clinical requirements,experiments were conducted to measure human blood glucose by a novel measurement method our group proposed.Methods The blood flow of the tested parts was stopped by pressure,and dynamic distribution of transmission spectra was measured by time-correlated single-photon counting （TCSPC） technology under the dual wavelength light incident.Oral glucose tolerance test （OGTT） was conducted on three human subjects,and the early arriving photons were selected by Laplace transform.Meanwhile,the human blood glucose concentration was measured using the Roche glucose meter.Results The best curve fitting was got when the Laplace parameter was 1Gs^-1 （determining parameter R^2=0.0922）.Conclusions The experimental results showed that better measurement accuracy can be obtained by selecting appropriate Laplace parameter,and noninvasive measurement of human blood glucose under flow control of time gate was feasible.