2型糖尿病并肾病早期相关危险因素分析 |
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引用本文: | 刘发林,;王利荣,;黄海晏,;孙家忠. 2型糖尿病并肾病早期相关危险因素分析[J]. 医学临床研究, 2014, 0(5): 960-963 |
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作者姓名: | 刘发林, 王利荣, 黄海晏, 孙家忠 |
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作者单位: | [1]武汉大学基础医学院,湖北武汉430071; [2]湖北航天医院内分泌科,湖北孝感432100; [3]武汉大学中南医院内分泌科,湖北武汉430071 |
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摘 要: | 【目的】探讨2型糖尿病(T2DM)合并糖尿病肾病早期(EDN)的危险因素,为糖尿病肾病(DN)的早期防治提供科学依据。【方法】将566例T2DM患者按24 h尿微量白蛋白水平分为DN早期组(DN组,尿白蛋白30~300 mg/24 h)和单纯2型糖尿病组(DM组,尿白蛋白<30 mg/24 h),比较两组在高血压病史、脂肪肝病病史、吸烟史及糖尿病病程、体质量指数(BMI)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、尿酸(UA)、糖化血红蛋白(HBA1C)、空腹C肽(FCP)、半小时C肽(0.5 hPCP)、2 hC肽(2 hPCP)等方面的差异,并进行比较分析。【结果】DN组和 DM组病程、合并高血压比例、吸烟比例、BMI、HDL-C、TG、UA水平相比较差异有显著性(P<0.05),脂肪肝发生率、HBA1C、FCP、0.5 hPCP、2hPCP、LDL-C水平相比较差异无显著性(P>0.05)。DN组的病程、BMI、TG、UA水平较高,HDL-C水平较低。Logistical 回归分析显示,糖尿病病程、合并高血压、高 BMI 及高 LDL-C 是 DN 的影响因素。【结论】糖尿病病程长、合并高血压、高 BMI及高 LDL-C是早期 DN的危险因素,糖尿病病人应戒烟,严格控制血压、血糖和体质量,定期监测尿酸、血脂,积极纠正脂代谢紊乱,可预防DN的发生和发展。
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关 键 词: | 糖尿病 2型 并发症 糖尿病肾病 危险因素 |
Analysis of the Correlative Risk Factors of Early Diabetic Nephropathy in Type 2 Diabetes Mel-litus |
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Affiliation: | LIU Fa-lin, WANG Li-rong, HUANG Hai-yan,et al ( Department of Endocrinology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, (Ynina ) |
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Abstract: | [Objective]To explore the risk factors of early diabetic nephropathy(EDN)in type 2 diabetes mellitus(T2DM)in order to provide the scientific evidence for early prevention and treatment of type 2 diabetic nephropathy (DN).[Methods]According to 24h urinary albumin level,566 T2DM patients were divided into EDN group(EN group,urinary albumin was 30~300mg/24h)and simple T2DM group(DM group,urinary albumin0.05).The duration,BMI,TG and UA in EN group were lower.Lo-gistical regression analysis showed that the duration of diabetes mellitus,the hypertension,high BMI and high LDL-C were the influencing factors of DN.[Conclusion]Long duration of diabetes mellitus,hypertension, high BMI and high LDL-C are the risk factors of EDN.Diabetic patients should stop smoking,strictly control blood pressure,blood sugar and body weight,regularly monitor UA and blood lipids and actively correct lipid metabolism disorders in order to prevent the occurrence and development of DN. |
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Keywords: | Diabetes Mellitus,Type 2/CO Diabetic Nephropathies Risk Factors |
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