Positive and negative effects of glitazones in carcinogenesis: Experimental models vs. clinical practice |
| |
| Authors: | Bianka Bojková Peter Orendáš Peter Kubatka Martin Péč Monika Kassayová Terézia Kisková Karol Kajo |
| |
| Institution: | 1. Department of Animal Physiology, Faculty of Science, Institute of Biology and Ecology, P.J. Šafárik University, Moyzesova 11, 041 67 Košice, Slovak Republic;2. Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University, Malá Hora 4, 037 54 Martin, Slovak Republic;3. Department of Pathology, Slovak Medical University and St. Elisabeth Oncology Institute, Heydukova 10, 811 08 Bratislava, Slovak Republic |
| |
| Abstract: | Diabetes increases cancer risk, which may be modulated by careful choice of treatment. Experimental reports showed efficacy of glitazones in various in vitro and in vivo models of carcinogenesis, but procarcinogenic effects in some models were reported too, and, similarly, data on cancer incidence in glitazone users are inconsistent. This review summarizes oncostatic effects of glitazones in preclinical and clinical studies and brings a brief summary of their impact on cancer risk in diabetic patients, with a focus on the association between pioglitazone use and bladder cancer. |
| |
| Keywords: | Glitazones Cancer Pioglitazone Bladder cancer |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
