控制性促排卵中大卵泡穿刺的研究

目的控制性促排卵周期中对发育过快的大卵泡进行穿刺，以使卵泡同步化发育得以改善临床的疗效。方法将59例卵泡发育不同步患者作回顾性研究，其中行大卵泡穿刺为试验组（n=28），未行大卵泡穿刺为对照组（n=31），对入选患者的病历资料进行统计分析，评估促排卵过程中行大卵泡穿刺的效果及对助孕结果的影响。结果试验组较对照组Gn天数与用量有所增加（P〈0．05），但获卵数、成熟卵率、临床妊娠率均较对照组高，差异有统计学意义（P〈0．05）。两组卵裂率、流产率等差异均无统计学意义。结论在超促排卵方案中，对于卵泡生长发育同步性差的可考虑采用提前进行大卵泡穿刺，使剩余卵泡发育的同步性增加，以获得较好的妊娠结局。

Effects of big ovarian follocles puncture in control ovarian stimulation

Objective To assess the clinic effects of big ovarian follocles puncture on synchronize the follicular develop-ment in control ovarian stimulation. Methods Fifty-nine patients follicular development asynchronization were randomized di-vided into test group, who punctured the big ovarian follocles during the IVF cycle (n=28) ,and control group, who did not re-ceive that treatment (n=31). A retrospective analysis of the anamnestic data of the patients was carried out for the assessment ofthe ovulation promoting effect of the big ovarian follocles puncture and the outcome of the IVF-ET operation. Results Compared with the control group, the days were increased and gonadotropin were more consumed in test group (P<0. 05). The number of eumulus-oocyte complexes (COCs), the ratio of ovium and the clinical pregnancy rates were increased in test group (P<0. 05), hut no significant differences were observed regarding the ratio of cleavage and abortion rates. Conclusion The patients follicu-lar development asynchronization may receive the big ovarian follocles puncture in control ovarian stimulation to synchronize the follicular development, and gain a good pregnancy outcome.