On the dual contrast enhancement mechanism in frequency‐selective inversion‐recovery magnetic resonance angiography (IRON‐MRA) |
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| Authors: | Evert‐jan Vonken Grigorios Korosoglou Jing Yu Michael Schär Ralph Weissleder Matthias Stuber |
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| Affiliation: | 1. Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA;2. University of Heidelberg, Department of Cardiology, Heidelberg, Germany;3. Philips Healthcare, Cleveland, Ohio, USA;4. Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA |
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| Abstract: | The susceptibility of blood changes after administration of a paramagnetic contrast agent that shortens T1. Concomitantly, the resonance frequency of the blood vessels shifts in a geometry‐dependent way. This frequency change may be exploited for incremental contrast generation by applying a frequency‐selective saturation prepulse prior to the imaging sequence. The dual origin of vascular enhancement depending first on off‐resonance and second on T1 lowering was investigated in vitro, together with the geometry dependence of the signal at 3T. First results obtained in an in vivo rabbit model are presented. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc. |
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| Keywords: | magnetic resonance angiography off‐resonance imaging blood‐pool contrast agent susceptibility contrast background suppression |
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