PRIMARY GASTRIC PLASMACYTOMA REFRACTORY TO HELICOBACTER PYLORI ERADICATION THERAPY |
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| Authors: | Naruo Kawasaki Koji Nakada Yuko Kawasaki Yutaka Suzuki Katsunori Masuda Yoshio Miyazawa Hideyuki Kashiwagi Katsuhiko Yanaga |
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| Affiliation: | 1. Department of Surgery, Jikei University School of Medicine,;2. Department of Internal Medicine, NTV‐Avenue Clinic,;3. Department of Endoscopy, St Luke's International Hospital, Tokyo and;4. Department of Pathology, Chigasaki Tokusyukai Medical Center, Kanagawa, Japan |
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| Abstract: | A 49‐year‐old woman underwent upper gastrointestinal endoscopic examination for epigastric discomfort, revealing giant folds on the greater curvature of the stomach. Histological examinations of biopsy specimens taken from the giant folds showed signs of chronic inflammation, and Helicobacter pylori was also identified. She underwent first‐step H. pylori eradication. On follow‐up endoscopy, H. pylori was not identified. However, endoscopic findings were unchanged and repeated biopsies showed dense infiltration of atypical plasma cells. No proliferation of centrocyte‐like cells was seen. Immunohistochemically, plasma cells were positive for λ‐chain. Primary gastric plasmacytoma was diagnosed. Total gastrectomy was carried out with splenectomy and regional lymph node dissection. The patient remains disease free as of 6 years postoperatively. |
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| Keywords: | eradication extramedullary plasmacytoma Helicobacter pylori infection primary gastric plasmacytoma |
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