Distinct patterns of regional cerebral glucose metabolism in Parkinson's disease with and without mild cognitive impairment |
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| Authors: | Yoshiyuki Hosokai MS Yoshiyuki Nishio MD PhD Kazumi Hirayama MD PhD Atsushi Takeda MD PhD Toshiyuki Ishioka MS Yoichi Sawada MS Kyoko Suzuki MD PhD Yasuto Itoyama MD PhD Shoki Takahashi MD PhD Hiroshi Fukuda MD PhD Etsuro Mori MD PhD |
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| Affiliation: | 1. Department of Radiological Technology and Science, School of Health Science, Tohoku University, Sendai, Japan;2. Department of Behavioral Neurology and Cognitive Neuroscience, Graduate School of Medicine, Tohoku University, Sendai, Japan;3. Department of Neurology, Graduate School of Medicine, Tohoku University, Sendai, Japan;4. Department of Clinical Neuroscience, Graduate School of Medicine, Yamagata University, Yamagata, Japan;5. Department of Diagnostic Radiology, Graduate School of Medicine, Tohoku University, Sendai, Japan;6. Department of Radiology and Nuclear Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan |
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| Abstract: | There is no consensus with regard to the clinical and neuroimaging characteristics of prodromal dementia in Parkinson's disease (PD). To delineate functional neuroimaging features of PD with mild cognitive impairment (PDMCI) and with no cognitive impairment (PDNC), we compared regional cerebral glucose metabolism (CMRglc) amongst 13 patients with PDMCI, 27 with PDNC, and 13 healthy controls. The PDNC patients had limited areas of hypometabolism in the frontal and occipital cortices. In the PDMCI patients, there were extensive areas of hypometabolism in the posterior cortical regions, including the temporo‐parieto‐occipital junction, medial parietal, and inferior temporal cortices. The present results suggest that posterior cortical dysfunction is the primary neuroimaging feature of PD patients at risk for dementia. © 2009 Movement Disorder Society |
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| Keywords: | Parkinson's disease mild cognitive impairment 18F‐FDG positron emission tomography |
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