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Pre‐freeze and post‐thaw characteristics on chimerism patterns in double‐unit cord blood transplantation |
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| Authors: | Tang‐Her Jaing MD Pei‐Kwei Tsay PhD Tung‐Liang Lin MD Chao‐Ping Yang MD Iou‐Jih Hung MD Yu‐Chuan Wen RN |
| Institution: | 1. Division of Hematology and Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan;2. Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan;3. Department of Public Health and Center of Biostatistics, College of Medicine, Chang Gung University, Taoyuan, Taiwan;4. Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan;5. Department of Nursing, Chang Gung Memorial Hospital, Chang Gung University, Linkou, Taoyuan, Taiwan |
| Abstract: | We analyzed the pre‐freeze and post‐thaw characteristics on chimerism patterns in 20 cases of double‐unit cord blood transplantation. The cord blood units (CBUs) were a 4/6 HLA match or better with recipients and achieved a minimum combined precryopreservation cell dose of 3.7 × 107 total nucleated cell (TNC)/kg. The unit with a higher cell dose was infused first. All evaluable patients engrafted at a median of 18 days. By day 42, neutrophil engraftment was derived from both donors in 63% of cases and a single donor in 37% of patients. By day 100, one unit predominated in 80% of the patients. Higher pre‐freeze TNC and CD34+ cell doses were associated with cord predominance in 67% of patients. Pediatr Blood Cancer 2009;52:547–550. © 2008 Wiley‐Liss, Inc. |
| Keywords: | cell dose double cord blood transplantation neutrophil engraftment predominant unit |