Resolution‐recovery for EPR imaging of free radical molecules in mice |
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| Authors: | Yusuke Ikebata Hideo Sato‐Akaba Takashi Aoyama Hirotada Fujii Kouichi Itoh Hiroshi Hirata |
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| Institution: | 1. Department of Electrical Engineering, Yamagata University, Yonezawa, Yamagata, Japan;2. Division of Bioengineering and Bioinformatics, Graduate School of Information Science and Technology, Hokkaido University, Sapporo, Hokkaido, Japan;3. Graduate Program of Human Sensing and Functional Sensor Engineering, Yamagata University, Yonezawa, Yamagata, Japan;4. School of Health Sciences, Sapporo Medical University, Sapporo, Hokkaido, Japan;5. Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Kagawa, Japan |
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| Abstract: | A method of post‐processing to enhance the image resolution of the distribution of free radical molecules obtained with continuous‐wave electron paramagnetic resonance (CW‐EPR) imaging is reported. The low spatial resolution of EPR imaging, which has created difficulties in biomedical applications, was overcome by the method of resolution‐recovery for EPR imaging. High spatial resolution images for the distribution of free radical molecules with a very short relaxation time were obtained with this method. The method's two‐step postprocessing consists of conventional deconvolution and filtered back‐projection and a process of iterative deconvolution. The resolution‐recovery method was demonstrated with three‐dimensional (3D) imaging of stable nitroxyl radicals in mouse head. In phantom experiments with a solution of triarylmethyl (TAM) radicals, the spatial resolution was improved by a factor of 7 with the resolution‐recovery method. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc. |
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| Keywords: | resolution recovery free radicals EPR imaging iterative deconvolution mice |
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