MMP‐9 and TIMP‐1 in the cord blood of premature infants developing BPD |
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| Authors: | Shinnosuke Fukunaga MD Takashi Ichiyama MD Shinji Maeba MD Masayuki Okuda MD Masahiko Nakata MD Norihiro Sugino MD Susumu Furukawa MD |
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| Affiliation: | 1. Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan;2. Perinatal Care Center, Yamaguchi University Hospital, Yamaguchi, Japan;3. Department of Environmental Science and Engineering, Yamaguchi University Graduate School of Science and Engineering, Yamaguchi, Japan |
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| Abstract: | We investigated matrix metalloproteinase‐9 (MMP‐9) and tissue inhibitor of metalloproteinase 1 (TIMP‐1) levels in the cord blood of 29 premature infants who were <30 weeks gestation. One, 8, and 14 infants developed severe, moderate and mild bronchopulmonary dysplasia (BPD), respectively, and 6 did not. MMP‐9 and TIMP‐1 levels in the cord blood were determined by ELISA. MMP‐9/TIMP‐1 ratios in the cord blood of infants who developed severe or moderate BPD (n = 9) were significantly higher than those who developed mild BPD or did not develop BPD (n = 20; P = 0.015). Multivariate linear regressions demonstrated that MMP‐9 levels and MMP‐9/TIMP‐1 ratios in the cord blood of the premature infants correlated with the oxygen supplementation period (r = 0.58, P = 0.003 and r = 0.41, P = 0.030, respectively). The MMP‐9 levels and MMP‐9/TIMP‐1 ratios correlated with the severity of maternal chorioamnionitis (both trend P = 0.006). The MMP‐9 levels and MMP‐9/TIMP‐1 ratios in the cord blood may be related to the pathogenesis and severity of BPD and maternal chorioamnionitis. Pediatr Pulmonol. 2009; 44:267–272. © 2009 Wiley‐Liss, Inc. |
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| Keywords: | bronchopulmonary dysplasia chorioamnionitis cord blood matrix metalloproteinase‐9 tissue inhibitor of metalloproteinase‐1 |
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