Fatigue in Japanese patients with Parkinson's disease: A study using Parkinson fatigue scale |
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| Authors: | Yasuyuki Okuma MD Satoshi Kamei MD Akihiko Morita MD Fumihito Yoshii MD Toshimasa Yamamoto MD Shiori Hashimoto MD Hiroya Utsumi MD Taku Hatano MD Nobutaka Hattori MD Miyuki Matsumura MD Kazushi Takahashi MD Shigeru Nogawa MD Yuka Watanabe MD Tomoyuki Miyamoto MD Masayuki Miyamoto MD Koichi Hirata MD |
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| Affiliation: | 1. Department of Neurology, Juntendo University Shizuoka Hospital, Shizuoka, Japan;2. Division of Neurology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan;3. Department of Neurology, Tokai University School of Medicine, Kanagawa, Japan;4. Department of Neurology, Faculty of Medicine, Saitama Medical University, Saitama, Japan;5. Department of Neurology, Tokyo Women's Medical University, Tokyo, Japan;6. Third Department of Internal Medicine, Division of Neurology, Tokyo Medical University, School of Medicine, Tokyo, Japan;7. Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan;8. Institute of Geriatrics, Tokyo Women's Medical University, Tokyo, Japan;9. Department of Neurology, Keio University School of Medicine, Tokyo, Japan;10. Department of Internal Medicine, Tokyo Dental College Ichikawa General Hospital, Chiba, Japan;11. Department of Neurology, Dokkyo Medical University, Tochigi, Japan |
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| Abstract: | The objective of this multicenter cross‐sectional study was to determine the prevalence of fatigue and factors contributing to it in a large sample of Japanese patients with Parkinson's disease (PD). We used the 16‐item Parkinson Fatigue Scale (PFS‐16), which was designed to assess fatigue exclusively associated with PD. We carried out this study using PFS‐16, the Unified Parkinson's Disease Rating Scale, Zung's Self‐Rating Depression Scale, Parkinson's Disease Sleep Scale (PDSS), and the PD quality of life (QOL) scale (PDQ‐39) by interview using questionnaires and physical examination by neurologists in 361 nondemented PD patients. Fatigue (an average PFS score of 3.3 or greater) was revealed in 151 patients (41.8%). Multiple logistic regression analysis indicated that the significant independent variables related to the presence of fatigue were the scores of PDSS and PDQ‐39. Depression score was not a significant contributing factor. Our study revealed that the prevalence of fatigue in Japanese PD patients is as high as that in Western countries, and that fatigue is a relatively independent symptom, although sleep disturbance may be associated with fatigue. Since fatigue is significantly related to QOL reduction, therapeutic interventions including treatment of sleep disturbance are important. © 2009 Movement Disorder Society |
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| Keywords: | Parkinson's disease fatigue sleep disorder quality of life |
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