复方丹参滴丸对口腔扁平苔藓患者血液流变学的影响

目的 :探讨复方丹参滴丸口服治疗对口腔扁平苔藓 (OLP)患者外周血液流变学的影响。方法 :选择 46名OLP患者 ,用复方丹参滴丸口服治疗 8周 ( 3次 /d ,每次 10粒 ) ,治疗前后取患者静脉血 ,分别进行血液流变学检测 ,同时观察治疗结果。结果 :经复方丹参滴丸 8周治疗后 ,在 46例OLP患者中 ,显效 5例、有效 33例、无效 8例 ,有效率约 83% ,同时 ,患者的全血粘度 (含高切与低切 )、血浆粘度、红细胞聚集指数、血小板聚集率、纤维蛋白原、血沉等 7项指标较治疗前明显下降 ,两者存在统计学差异 (P <0 .0 5或P <0 .0 1) ,而红细胞压积在治疗前后无明显差别 (P >0 .0 5 )。结论 :复方丹参滴丸能明显改善OLP患者的血液流变学状况 ,对该病有一定的疗效 ,且不良反应极小。

A priliminary observation of composite Danshen droplet pills on hemorheology of patientswith oral lichen planus

?Objective:To study the influence of composite Danshen droplet pills on hemorheology in peripheral blood of patients with oral lichen planus (OLP).Methods:46 patients with OLP were treated by composite Danshen droplet pills for 8 weeks (oral administration,3 times/day,10 granules/time).The venous blood was taken and the hemorheology was studied with a LBY N6A hemorheology test machine before and after the treatment.Results:Effective results were observed in 33 patient and obvious effective results in 5,while no treating effect was found in 8 after treatment.Whole blood viscosity,blood plasm viscosity,erythrocyte aggregation indexs,thrombocyte aggregation rate,fibrinogen and ESR of the OLP patients were decreased ( P <0.05 or P <0.01),while hematocrit did not change ( P >0.05).Conclusion:The composite Danshen droplet pills may improve the hemorheology of OLP patients.