| 亚砷酸钠对几个肿瘤相关基因表达水平影响的研究 |
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| 引用本文： | 姚华,王国荃,朱滨,孙悦,景丰香,赵建龙. 亚砷酸钠对几个肿瘤相关基因表达水平影响的研究[J]. 地方病通报, 2002, 17(4): 1-4 |
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| 作者姓名： | 姚华 王国荃 朱滨 孙悦 景丰香 赵建龙 |
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| 作者单位： | 新疆医科大学公共卫生学院环境卫生教研室,新疆,乌鲁木齐,830054;中国科学院上海冶金研究所,上海,200050 |
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| 基金项目： | 国家自然科学基金 (地区联合 )资助项目 (399690 0 4 ) |
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| 摘 要： | 为探讨砷作用的分子遗传机制，采用寡核苷酸芯片和cDNA芯片两种方法来研究砷对已知基因(c-myc和p53）和未知基因表达水平的影响，结果表明亚砷酸钠造肝细胞中p53抑癌基因、人肿瘤抑制基因表达增强，c-myc癌基因和解偶联蛋白基因表达减弱，说明亚砷酸钠在正常人肝细胞中表现出抗癌效应并能促进能量储存。
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| 关 键 词： | 砷 肿瘤 基因 |
| 文章编号： | 1000-3711(2002)04-0001-04 |
| 修稿时间： | 2002-05-29 |
The Study on Several Tumor Genes Expression Caused by NaAsO2 in Liver Cells |
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| YAO Hua ,WANG Guo quan ,ZHU Bin ,SUN Yue ,JING Feng xiang ,ZHAO Jian long. The Study on Several Tumor Genes Expression Caused by NaAsO2 in Liver Cells[J]. Endemic Diseases Bulletin, 2002, 17(4): 1-4 |
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| Authors: | YAO Hua WANG Guo quan ZHU Bin SUN Yue JING Feng xiang ZHAO Jian long |
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| Affiliation: | YAO Hua 1,WANG Guo quan 1,ZHU Bin 2,SUN Yue 2,JING Feng xiang 2,ZHAO Jian long 2 |
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| Abstract: | Oligonucleotide microarray and cDNA microarray were used to research expression level of the known and unknown genes of NaAsO 2 for exploring the molecular mechanism of NaAsO 2. Results showed NaAsO 2 induced p53 and hTSG101 gene expression, and inhibited C myc and UCP 2 gene expression in human liver cells. That meant NaAsO 2 appeared anti cancer effect and promoted the store of energy in human liver cells. |
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| Keywords: | As Cancer Gene |
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