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Mean Platelet Volume Is Increased in Infective Endocarditis and Decreases after Treatment
Authors:Atilla Icli  Senol Tayyar  Ercan Varol  Fatih Aksoy  Akif Arslan  Ibrahim Ersoy  Selahaddin Akcay
Institution:aDepartment of Cardiology, Ahi Evran University Education and Research Hospital, Kirsehir, Turkey;bFaculty of Medicine, Suleyman Demirel University, Isparta, Turkey
Abstract:

Objectives

The aim of this study was to assess the mean platelet volume (MPV), an indicator of platelet activation in patients with infective endocarditis.

Subjects and Methods

Twenty-nine patients with infective endocarditis and 29 healthy subjects were studied. Plasma MPV values in patients and control subjects were measured on admission and after 2 weeks of specific treatment of infective endocarditis.

Results

The MPV was significantly higher among patients with infective endocarditis when compared with the control group (9.86 ± 1.1 vs. 8.0 ± 1.0 fl, respectively; p < 0.01). The MPV values of patients with infective endocarditis decreased significantly after treatment from 9.86 ± 1.1 to 7.86 ± 1.0 fl (p < 0.01). Total platelet counts increased significantly after treatment from 193.4 ± 96.5 × 109 to 243.7 ± 92.4 × 109 (p = 0.04).

Conclusion

MPV values were higher in patients with infective endocarditis and decreased significantly after treatment. Elevated MPV values indicate that patients with infective endocarditis have increased platelet activation and infective endocarditis treatment decreases this platelet activation by decreasing MPV.Key Words: Mean platelet volume, Infective endocarditis, Thrombus, Vegetation
Keywords:
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