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Serum uric acid level in newly diagnosed essential hypertension in a Nepalese population: A hospital based cross sectional study
Authors:Bibek Poudel  Binod Kumar Yadav  Arun Kumar  Bharat Jha  Kanak Bahadur Raut
Affiliation:1. Department of Biochemistry, Manipal College of Medical Sciences (MCOMS), Manipal Teaching Hospital (MTH), Pokhara, Nepal;2. Research Institute of Clinical Medicine, Chonbuk National University Medical School and Hospital, Jeonju 561-712, South Korea;3. Department of Biochemistry, Institute of Medicine, Tribhuvan University Teaching Hospital (Institute of Medicine, TUTH), Kathmandu, Nepal;4. Department of Internal Medicine, Institute of Medicine, Tribhuvan University Teaching Hospital (Institute of Medicine, TUTH), Kathmandu, Nepal;1. Department of Respiratory Medicine, M.M Institute of Medical Sciences & Research, Mullana, Ambala, Haryana, India;2. Department of Biochemistry, M.M Institute of Medical Sciences & Research, Mullana, Ambala, Haryana, India;3. Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan;4. School of Medicine, China Medical University, Taichung, Taiwan;1. Department of Otorhinolaryngology-Head and Neck Surgery;2. Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University Hospital, Daegu, Korea;1. Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, United States;2. Medical Oncology Service, National Cancer Institute, National Institute of Health, Bethesda, MD, United States;3. Channing Division of Network Medicine, Department of Medicine, Brigham and Women''s Hospital and Harvard Medical School, Boston, MA, United States;4. Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States;5. Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States;6. Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States;7. Department of Pathology, Children’s Hospital Medical Center, Boston, MA, United States;8. Department of Nutrition, Harvard School of Public Health, Boston, MA, United States
Abstract:

Objective

To develop the missing link between hyperuricemia and hypertension.

Methods

The study was conducted in Department of Biochemistry in collaboration with Nephrology Unit of Internal Medicine Department. Hypertension was defined according to blood pressure readings by definitions of the Seventh Report of the Joint National Committee. Totally 205 newly diagnosed and untreated essential hypertensive cases and age-sex matched normotensive controls were enrolled in the study. The potential confounding factors of hyperuricemia and hypertension in both cases and controls were controlled. Uric acid levels in all participants were analyzed.

Results

Renal function between newly diagnosed hypertensive cases and normotensive healthy controls were adjusted. The mean serum uric acid observed in newly diagnosed hypertensive cases and in normotensive healthy controls were (290.05±87.05) µmol/L and (245.24±99.38) µmol/L respectively. A total of 59 (28.8%) participants of cases and 28 (13.7%) participants of controls had hyperuricemia (odds ratio 2.555 (95% CI: 1.549-4.213), P<0.001).

Conclusions

The mean serum uric acid levels and number of hyperuricemic subjects were found to be significantly higher in cases when compared to controls.
Keywords:Newly diagnosed hypertension   Serum uric acid   Hyperuricemia   Joint National Committee
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