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Molecular docking to Toxoplasma gondii thymidylate synthase-dihydrofolate reductase and efficacy of raltitrexed in infected mice |
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| Authors: | de Paula Reis Michelle de Lima Daniely Alves Pauli Karoline Bach Andreotti Carlos Eduardo Linhares de Moraes André Luiz Soares Gonçalves Daniela Dib Navarro Italmar Teodorico Bueno Paulo Sérgio Alves Seixas Flavio Augusto Vicente Gasparotto Junior Arquimedes Lourenço Emerson Luiz Botelho |
| Affiliation: | 1.Laboratory of Preclinical Research of Natural Products, Universidade Paranaense, Umuarama, PR, Brazil ;2.Animal Science Department, Londrina State University, Londrina, PR, Brazil ;3.Laboratory of Structural Biochemistry, Universidade Estadual de Maringá, Maringá, PR, Brazil ;4.Laboratory of Electrophysiology and Cardiovascular Pharmacology, Faculty of Health Sciences, Universidade Federal da Grande Dourados, Rodovia Dourados-Itahum, km 12, P.O. Box 533, 79, Dourados, MS, 804-970, Brazil ; |
| Abstract: | Parasitology Research - Toxoplasmosis is a zoonosis of worldwide distribution. Currently, two drugs, pyrimethamine and sulfadiazine, are used as a reference in the treatment of toxoplasmosis, but... |
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