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Placental tissue stem cells and their role in neonatal diseases |
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| Institution: | 1. Division of Neonatology and Pulmonary Biology, Perinatal Institute, Cincinnati Children''s Hospital Medical Center, Cincinnati, OH, USA;2. Department of Pediatrics, Cincinnati Children''s Hospital Medical Center, Cincinnati, OH, USA;3. Center for Lung Regenerative Medicine, Cincinnati Children''s Hospital Medical Center, Cincinnati, OH, USA;4. Division of Developmental Biology, Cincinnati Children''s Hospital Medical Center, Cincinnati, OH, USA;1. Department of Development and Regeneration, Belgium;2. Department of Pharmaceutical and Pharmacological Sciences KU Leuven, Leuven, Belgium;3. Hospital Pharmacy, Erasmus MC, Rotterdam, the Netherlands;4. Division of Clinical Pharmacology, Department of Pediatrics, Children''s National Hospital, Washington, DC, United States;5. Division of Paediatric Pharmacology and Pharmacometrics, University Children''s Hospital Basel, University of Basel, Switzerland;6. Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center-Sophia Children''s Hospital, Rotterdam, the Netherlands;1. Otolaryngology Department, Hospital de Clínicas de Porto Alegre, Rio Grande do Sul, Brazil;2. Programa de Pós-Graduação em Saúde da Criança e do Adolescente, Universidade Federal do Rio Grande do Sul, Rio Grande do Sul, Brazil;1. Interdisciplinary Center for Cleft Palate & Craniofacial Malformations and Department of Neonatology, Tübingen University Hospital, Tübingen, Germany;2. Department of General Pediatrics, Reference Center for Rare Diseases “Pierre Robin Sequences and Congenital Sucking-swallowing Troubles”, Necker University Hospital, Paris University, France;3. Department of Plastic Reconstructive and Hand Surgery, Amsterdam UMC, Emma Children''s Hospital - Location AMC, University of Amsterdam, the Netherlands;4. Department of Paediatric Respiratory Medicine, Great Ormond Street Hospital, London, UK |
| Abstract: | Neonatal diseases such as hypoxic ischemic encephalopathy, diseases of prematurity and congenital disorders carry increased morbidity and mortality. Despite technological advancements, their incidence remains largely unabated. Stem cell (SC) interventions are novel therapies in the neonatal world. In pre-clinical models of neonatal diseases, SC applications have shown encouraging results. SC sources vary, with the bone marrow being the most utilized. However, the ability to harvest bone marrow SCs from neonates is limited. Placental-tissue derived SCs (PTSCs), provide an alternative and highly attractive source. Human placentas, the cornerstone of fetal survival, are abundant with such cells. Comparing to adult pools, PTSCs exhibit increased potency, decreased immunogenicity and stronger anti-inflammatory effects. Several types of PTSCs have been identified, with mesenchymal stem cells being the most utilized population. This review will focus on PTSCs and their pre-clinical and clinical applications in neonatology. |
| Keywords: | Stem cells Placenta Bronchopulmonary dysplasia Congenital diaphragmatic hernia Hypoxic ischemic encephalopathy Intraventricular hemorrhage Necrotizing enterocolitis Cell therapy Regenerative medicine Tissue bioengineering SC"} {"#name":"keyword" "$":{"id":"kwrd0065"} "$$":[{"#name":"text" "_":"stem cell PTSC"} {"#name":"keyword" "$":{"id":"kwrd0075"} "$$":[{"#name":"text" "_":"placental-tissue derived stem cell MSC"} {"#name":"keyword" "$":{"id":"kwrd0085"} "$$":[{"#name":"text" "_":"mesenchymal stromal/stem cell ESC"} {"#name":"keyword" "$":{"id":"kwrd0095"} "$$":[{"#name":"text" "_":"epithelial stem cell HPC"} {"#name":"keyword" "$":{"id":"kwrd0105"} "$$":[{"#name":"text" "_":"hematopoetic progenitor cell HSC"} {"#name":"keyword" "$":{"id":"kwrd0115"} "$$":[{"#name":"text" "_":"hematopoetic stem cell EPC"} {"#name":"keyword" "$":{"id":"kwrd0125"} "$$":[{"#name":"text" "_":"endothelial progenitor cell ECFC"} {"#name":"keyword" "$":{"id":"kwrd0135"} "$$":[{"#name":"text" "_":"endothelial colony forming cell UC"} {"#name":"keyword" "$":{"id":"kwrd0145"} "$$":[{"#name":"text" "_":"umbilical cord UCB"} {"#name":"keyword" "$":{"id":"kwrd0155"} "$$":[{"#name":"text" "_":"umbilical cord blood MNC"} {"#name":"keyword" "$":{"id":"kwrd0165"} "$$":[{"#name":"text" "_":"mononuclear cell DMSC"} {"#name":"keyword" "$":{"id":"kwrd0175"} "$$":[{"#name":"text" "_":"decidua mesenchymal stromal/stem cell CMSC"} {"#name":"keyword" "$":{"id":"kwrd0185"} "$$":[{"#name":"text" "_":"chorionic mesenchymal stromal/stem cell AMSC"} {"#name":"keyword" "$":{"id":"kwrd0195"} "$$":[{"#name":"text" "_":"amniotic membrane mesenchymal stromal/stem cells AESC"} {"#name":"keyword" "$":{"id":"kwrd0205"} "$$":[{"#name":"text" "_":"amniotic epithelial stem cell AFMSC"} {"#name":"keyword" "$":{"id":"kwrd0215"} "$$":[{"#name":"text" "_":"amniotic fluid membrane mesenchymal stromal/stem cell WJMSC"} {"#name":"keyword" "$":{"id":"kwrd0225"} "$$":[{"#name":"text" "_":"Wharton's jelly mesenchymal stromal/stem cell CPC"} {"#name":"keyword" "$":{"id":"kwrd0235"} "$$":[{"#name":"text" "_":"cardiac progenitor cell EV"} {"#name":"keyword" "$":{"id":"kwrd0245"} "$$":[{"#name":"text" "_":"extracellular vehicles AC"} {"#name":"keyword" "$":{"id":"kwrd0255"} "$$":[{"#name":"text" "_":"amnion cell BPD"} {"#name":"keyword" "$":{"id":"kwrd0265"} "$$":[{"#name":"text" "_":"bronchopulmonary dysplasia CDH"} {"#name":"keyword" "$":{"id":"kwrd0275"} "$$":[{"#name":"text" "_":"congenital diaphragmatic hernia CHD"} {"#name":"keyword" "$":{"id":"kwrd0285"} "$$":[{"#name":"text" "_":"congenital heart disease HLHS"} {"#name":"keyword" "$":{"id":"kwrd0295"} "$$":[{"#name":"text" "_":"hypoplastic left heart syndrome HIE"} {"#name":"keyword" "$":{"id":"kwrd0305"} "$$":[{"#name":"text" "_":"hypoxic ischemic encephalopathy IVH"} {"#name":"keyword" "$":{"id":"kwrd0315"} "$$":[{"#name":"text" "_":"intraventricular hemorhage MMC"} {"#name":"keyword" "$":{"id":"kwrd0325"} "$$":[{"#name":"text" "_":"meningomyelocele NEC"} {"#name":"keyword" "$":{"id":"kwrd0335"} "$$":[{"#name":"text" "_":"necrotizing enterocolitis TRASCET"} {"#name":"keyword" "$":{"id":"kwrd0345"} "$$":[{"#name":"text" "_":"transamniotic stem cell therapy |
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