| 产ESBLs大肠埃希菌和肺炎克雷伯菌检测及耐药性分析 |
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| 引用本文： | 刘水音,何晓锋,吴镝,张虎,焦力群.产ESBLs大肠埃希菌和肺炎克雷伯菌检测及耐药性分析[J].空军总医院学报,2009,25(2):71-72,74. |
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| 作者姓名： | 刘水音 何晓锋 吴镝 张虎 焦力群 |
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| 作者单位： | 1. 黑龙江省大庆龙南医院检验科,大庆,163453
2. 空军总医院感染控制科,北京,100142 |
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| 摘 要： | 目的研究产ESBLs大肠埃希菌和肺炎克雷伯菌检测及耐药性,指导临床合理应用抗菌药物。方法采用初筛试验和确证试验对临床分离的大肠埃希菌、肺炎克雷伯菌进行检测,以确定产ESBLs菌株,并进行抗生素耐药性分析。结果产ESBLs菌在大肠埃希菌和肺炎克雷伯菌中的检出率分别为44.8%和23.6%,对亚胺培南最为敏感,对头孢唑啉和氨苄西林耐药。结论临床对产ESBLs细菌治疗以碳青霉烯类药物为首选,含酶抑制剂复合药物部分有效。
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| 关 键 词： | β内酰胺酶类 大肠杆菌 克雷伯菌 肺炎 药物耐受性 |
ESBLs producing escherichia coli and klebsiella pneumoniae detection and analysis of drug resistance |
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| Institution: | LIU Shui-yin, HE Xiao-feng, WU Di, et al (Heilongjiang Daqing Long South Hospital Laboratory Medicine ,Daqing 163453, China) |
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| Abstract: | Objective To study the ESBLs producing Escherichia coli and Klebsiella pneumoniae detection and drug resistance to guide clinical rational use of antimierobial agents. Methods The screening test and confirmatory test against clinical isolates of Escherichia coli , Klebsiella pneumoniae testing to determine the strains producing ESBLs and conduct analysis of antibiotic resistance. Results The bacteria producing ESBLs in E. coli and Klebsiella pneumoniae in the detection rates were 44.8 % and 23.6%, the most sensitive to imipenem, for cefazolin and ampicillin resistance. Conclusion ESBLs producing bacteria on the therapy to carbapenem drugs of choice and compound drugs containing β- lactamases inhibitors partially effective. |
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| Keywords: | Beta-lactamases Eseherichia coli Klebsiella pneumoniae Drug Tolerance |
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