The T allele of the missense Glu(298)Asp endothelial nitric oxide synthase gene polymorphism is associated with coronary heart disease in younger individuals with high atherosclerotic risk profile. |
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| Authors: | Andreas Gardemann Jana Lohre Sevim Cayci Norbert Katz Harald Tillmanns Werner Haberbosch |
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| Affiliation: | 1. Institut für Klinische Chemie und Pathobiochemie, Klinikum der Justus-Liebig-Universität Gießen, Gaffky-Strasse 11, 35392 Gießen, Germany;2. Abteilung Kardiologie und Angiologie der Justus-Liebig-Universität Gießen, 35392 Gießen, Germany;1. Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina;2. Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina;3. Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, New York;4. Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee;5. Center for Applied Genomics and Precision Medicine, Duke University, Durham, North Carolina;1. Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada;2. Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, Germany;3. Section of Cardiology, Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada;4. Variety Children’s Heart Centre, University of Manitoba, Winnipeg, Manitoba, Canada;5. Department of Medical Genetics, Alberta Health Services, Calgary, Alberta, Canada;6. Department of Biochemistry and Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada;7. Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada;8. Cumming School of Medicine Centre for Health Genomics and Informatics, University of Calgary, Calgary, Alberta, Canada;9. Department of Human Genetics, The University of Chicago, Chicago, Illinois, USA;10. Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada;11. Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany |
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| Abstract: | AIMS: Nitric oxide (NO) plays a protective role during atherogenesis. In the endothelium, NO is synthesised by the constitutive NO synthase (ecNOS). We analysed the relation of the ecNOS Glu(298)Asp and 4a/b gene polymorphisms to coronary artery disease (CAD) and myocardial infarction (MI) in a population of 3250 German subjects (533 healthy controls and 2717 individuals who underwent coronary angiography). RESULTS: Although in the total sample, the ecNOS T allele was not associated with the risk of CAD (P=0.054) and the extent of this disease (P=0.078), a restriction to younger individuals (age
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