The relevance and role of vascular endothelial growth factor C,matrix metalloproteinase-2 and E-cadherin in epithelial ovarian cancer |
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Authors: | Ke-Jin Huang Li-Hua Sui |
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Institution: | (1) Department of Gynecology, The Third Affiliated Hospital of Harbin Medical University, 150040 Harbin, China; |
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Abstract: | We investigated the correlation of vascular endothelial growth factor C, matrix metalloproteinase-2, E-cadherin to explore
mechanisms of vascular endothelial growth factor C in the metastasis of ovarian cancer and the relationship of prognosis.
We applied immunohistochemistry to investigate the expression of vascular endothelial growth factor C, matrix metalloproteinase-2
and E-cadherin in ovarian tissues of 227 patients. We adopted Pearson chi-square test, Spearman correlation coefficient, univariate analysis, multivariate analysis, and Kaplan–Meier method. The positive
rate of vascular endothelial growth factor C, matrix metalloproteinase-2 and E-cadherin in ovarian cancer was higher than
that in borderline and benign tumor (P < 0.01). Vascular endothelial growth factor C was positively correlated with matrix metalloproteinase-2 (r = 0.665, P < 0.01) while negatively with E-cadherin(r = −0.185, P < 0.05). Univariate analysis showed clinical stage, pathologic grade, lymphatic metastasis, residual disease, chemotherapy,
ascites, vascular endothelial growth factor C, and matrix metalloproteinase-2-influenced survival time (P < 0.05). In Cox multivariate analysis, all the aforementioned factors were found to be independent prognostic factors except
pathologic grade. Vascular endothelial growth factor C was a new target to assess the prognosis of ovarian cancer. The expression
of vascular endothelial growth factor C in ovarian cancer was related to matrix metalloproteinase-2 and E-cadherin. |
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