| MMP-10、MMP-11及TIMP-2在胃癌组织中的表达 |
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| 引用本文： | 张慧,纪祥瑞,赵洁.MMP-10、MMP-11及TIMP-2在胃癌组织中的表达[J].青岛大学医学院学报,2010,46(2):119-121,124. |
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| 作者姓名： | 张慧 纪祥瑞 赵洁 |
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| 作者单位： | 1. 青岛大学医学院病理学教研室,山东,青岛,266021
2. 青岛大学医学院附属医院病理科 |
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| 摘 要： | 目的检测胃癌组织中基质金属蛋白酶-10（MMP-10）、基质金属蛋白酶-11（MMP-11）和基质金屑蛋白酶抑制因子-2（TIMP-2）的表达，探讨胃癌侵袭转移的分子机制。方法采用免疫组织化学方法检测MMP-10、MMP-11及TIMP-2在54例胃癌和20例癌周正常黏膜组织中的表达。结果胃癌组织中MMP-10、MMP-11及TIMP-2的表达与癌周正常黏膜组织比较，差异均有显著性（X^2=4．30～6．37，P〈0．05）。MMP-10和MMP-11的表达均与肿瘤大小、浸润深度、淋巴结转移及TNM分期有关（X^2=6．46—15．91，P〈0．05、0．01）；TIMP-2表达与淋巴结转移有关（X^2=4．91，P〈0．05）。MMP-10、MMP-11表达与TIMP-2表达呈正相关关系（r-0．29、0．34，P〈0．05）。结论MMP-10、MMP-11及TIMP-2的异常表达与胃癌的侵袭转移密切相关，可作为判断胃癌生物学行为和预后的重要指标。
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| 关 键 词： | 胃肿瘤 基质金属蛋白酶类 基质金属蛋白酶抑制剂 |
EXPRESSIONS OF MATRIX METALLOPROTEINASE-10, METALLOPROTEINASE-11 AND TISSUE INHIBITOR OF METALLOPROTEINASE-2 IN GASTRIC CARCINOMA |
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| ZHANG HUI,JI XIANG-RUI,ZHAO JIE.EXPRESSIONS OF MATRIX METALLOPROTEINASE-10, METALLOPROTEINASE-11 AND TISSUE INHIBITOR OF METALLOPROTEINASE-2 IN GASTRIC CARCINOMA[J].Acta Academiae Medicinae Qingdao Universitatis,2010,46(2):119-121,124. |
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| Authors: | ZHANG HUI JI XIANG-RUI ZHAO JIE |
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| Institution: | Department of Pathology;Qing-dao University Medical College;Qingdao 266021;China |
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| Abstract: | Objective To study the expressions of matrix metalloproteinase-10 (MMP-10), metalloproteinase 11 (MMP-11) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in gastric carcinoma and explore the mechanism of invasion and metastasis of the cancer.MethodsExpressions of MMP-10, MMP-11 and TIMP-2 were studied via immunohistochemistry in specimens resected from 45 patients with gastric carcinoma and 20 paraneoplastic normal mucosa (PNM).ResultsDifferences in expressions of MMP-10, MMP-11 and TIMP-2 were signifi... |
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| Keywords: | stomach neoplasms matrix metalloproteinases tissue inhibitor of metalloproteinase |
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