COX-2和Ki-67在尖锐湿疣组织中的表达及意义

目的探讨尖锐湿疣(CA)组织中环氧化酶-2(COX-2)和增殖指标K i-67的表达及意义。方法用免疫组化SP法分别检测COX-2蛋白和K i-67蛋白在38例CA组织和15例正常上皮组织中的表达。结果COX-2蛋白在CA组和正常皮肤组的阳性率分别为68.4%(26/38)和0,表达强度分别为3.921±0.254和0.883±0.088,二者在阳性率及表达强度上差异均有显著性(P均<0.01);K i-67蛋白在CA组和正常皮肤组的阳性率分别为84.2%(32/38)和60.0%(9/15),表达强度分别为0.234±0.021和0.05±0.006,二者阳性率差异无显著性(P>0.05),但表达强度差异有显著性(P<0.05);COX-2蛋白和K i-67蛋白之间的阳性表达呈正相关(r=0.497,P<0.01)。结论COX-2在CA发生、发展中起一定作用,与细胞的增殖有关。

Expression and Significance of COX-2 and Ki-67 Protein in Condyloma Acuminata

Objective To detect COX-2 and Ki-67 protein in keratinocytes of Condyloma acuminatum(CA),and to explore their roles in pathogenesis.Methods The expression of COX-2 and Ki-67 protein in 38 cases of CA and 15 normal controls was detected respectively with immunohistochemistry staining(SP).Results The positive rate of COX-2 protein was 68.4%(26/38),0.00%(0/15)in CA and normal skin tissue respectively.The expression of intensity was 3.921±0.254,0.883±0.088 respectively.There was significant difference in the expression of COX-2 protein between in the CA and normal skin tissues(P<0.01);The positive rate of Ki-67 protein was 84.2%(32/38),60.0%(9/15) in CA and normal skin tissue respectively,the expression of intensity was 0.234±0.021,0.05±0.006 respectively.There was no significant difference in the positive rate of Ki-67 protein between in the CA and normal skin tissues(P>0.05).But there was significant difference in the expression of intensity of Ki-67 protein between in the CA and normal skin tissues(P<0.01);There was a statistically positive correlation between COX-2 and Ki-67 protein overexpression in CA(r= 0.497,P<0.01).Conclusion There is a statistically positive correlation between COX-2 and Ki-67 protein overexpression in CA;the overexpression of COX-2 protein in CA may play some roles in process of tumour cell proliferation.