微波凝固对变应性鼻炎患者T淋巴细胞亚群的影响及意义

目的　探讨常年性变应性鼻炎 (PAR)患者细胞免疫功能状态及微波凝固治疗的作用机制。方法　观察组 2 5例PAR患者分别于微波治疗前以及治疗 1个月后应用免疫组化法检测鼻粘膜上皮和外周血CD3、CD4、CD8、CD4/CD8水平。健康对照组 1 5例亦作相应检测。结果　PAR患者治疗前鼻粘膜及外周血CD3、CD4明显高于正常人 ,CD8低于正常人 ,CD4/CD8比值升高 ,与正常人比较差异有显著性 (P <0 .0 5)。微波治疗后CD4明显减少 ,CD8升高 ,CD4/CD8接近于健康对照组。结论　PAR患者存在明显的细胞免疫功能障碍 ;微波局部凝固治疗可改善PAR患者的细胞免疫状况。

EFFECTS OF MICROWAVE TISSUE COAGULATION ON SYSTEMIC AND LOCAL INFILTRATING LYMPHOCYTES IN PATIENTS WITH PERENNIAL ALLERGIC RHINITIS

Objective To investigate the mechanism of microwave tissue coagulation (MTC) in perennial allergic rhinitis(PAR). Methods The levels of CD3,CD4,CD8,CD4/CD8 of 25 patients with PAR and 15 normal subjects were examined by Avidin-Biotin-enzyme Complex(ABC) before and after MTC. Results In the patients with PAR,the number of CD3,CD4 T lymphocytes and the ratio of CD4/CD8 increased while the number of CD8 T lymphocytes decreased.One month after MTC treatment,the number of CD3,CD4 T lymphocytes reduced and the increased CD4/CD8 ratio returned to normal and the number of CD8 T lymphocytes augmented. Conclusion The immune function of the patients with PAR is abnormal. MTC can regulate the imbalance of systemic and local immunity in patients with PAR.