镍铬合金和含钛镍铬合金在口腔唾液中析出镍元素的研究

目的研究镍铬合金、含钛镍铬合金烤瓷冠在人体口腔环境中镍离子的析出量。方法选择50例需行单个后牙烤瓷冠修复的患者，随机分为2组，一组制作镍铬合金烤瓷冠，另一组制作含钛镍铬合金烤瓷冠。在患者戴冠前，戴冠后1周、3个月、6个月采集唾液，用ICP-MS型电感耦合等离子体质谱仪测定唾液中镍离子的质量浓度。结果戴冠后1周，2组患者唾液中镍离子的质量浓度均有增加，6个月后恢复到戴冠前的水平。经统计学检验，戴冠前及戴冠后1周、3个月、6个月，2组患者唾液中镍的质量浓度经组内比较和组间比较均无统计学差异（P>0.05）。结论镍铬合金烤瓷冠、含钛镍铬合金烤瓷冠对患者唾液中的镍含量无明显影响。

Study on content of nickel in saliva released from the nickel-chromium and the nickel-chromium-titanium porcelain alloy

Objective The purpose of the study was to investigate the content of nickel (Ni) ion in patients' saliva after wearing the porcelain-fused-to nickel-chromium (Ni-Cr) crown or the porcelain-fused-to nickel-chromium titanium (Ni-Cr-Ti) crown. Methods 50 patients who had one molar or premolar needed repairing were selected and divided into two groups randomly. Patients in one group were fabricated with porcelain-fused-to Ni-Cr crown and the patients in the other group were fabricated with porcelain-fused-to Ni-Cr-Ti crown. Collect the patients' saliva before wearing, 1 week, 3 months, and 6 months after wearing. The content of Ni ion in saliva was detected by inductively coupled plasma mass spectrometry QCP-MS). Results The content of Ni ion in both groups increased at the first week, and go back after 6 months. There were no significant differences before wearing, 1 week, 3 months, and 6 months after wearing. There were no significant differences between the two groups. Conclusion Wearing the porce lain-fused-to Ni-Cr crown or the porcelain-fused-to Ni-Cr-Ti crown has no significant influence on the content of Ni ion in saliva.