Electrophysiological evidence for a projection from medial prefrontal and anterior limbic cortex toward the medial preoptic area in the cat |
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Authors: | B. I. Hyland N. E. Sirett J. I. Hubbard |
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Affiliation: | (1) Department of Physiology and Center for Neuroscience, University of Otago Medical School, P. O. Box 913, Dunedin, New Zealand |
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Abstract: | Summary Neurons in cat medial prefrontal cortex, anterior limbic cortex and possibly the indusium griseum were identified by antidromic invasion as having axonal projections towards the medial preoptic region, using both macro- and microstimulation techniques. These projecting axons were found to be of slow conduction velocity (0.2–4.8 m/s) and to in some cases also send branches towards the anteromedial thalamus, mediodorsal thalamus, ventromedial tegmentum, basolateral amygdala or medial forebrain bundle. Threshold-depth curves for axons excited by microstimulation in the medial preoptic region were very steep, with proportionality constants of 0.3–7.1 m/A. Calculations based on the threshold-depth curves confirmed that microstimulation was most probably only activating axons within the MPO, and current spread to lateral fibers of passage following macrostimulation in the MPO was not detected in the branching studies. |
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Keywords: | Prefrontal cortex Limbic cortex Medial preoptic area Axonal branching Electrophysiology Cat |
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