2015-2018年重庆市永川区中医院中药注射剂的不良反应分析

目的 分析了2015-2018年重庆市永川区中医院中药注射剂不良反应发生的规律及特点,为中药注射剂的合理使用提供参考依据。方法 采用回顾性分析方法,筛选符合要求的不良反应报告,记录相关信息,结合指南和文献进行分析。结果 符合要求的报告有180例,男女性比例接近,>70岁的老年人最多,构成比为24.44%;发生时间在用药10~30 min的构成比最高,达35.00%;主要表现以皮肤及附件损害为主,有97例（占53.89%）,其次表现为全身性症状,有32例（占17.17%）;不良反应发生涉及药品共有32种,引发不良反应排前3名的中药注射剂品种分别为注射用血塞通、舒血宁注射液、丹参川芎嗪注射液。结论 应加强中药注射剂不良反应监测工作,促进临床安全用药。

Analysis on adverse reactions of traditional Chinese medicine injection in Chongqing Yongchuan District Hospital from 2015 to 2018

Objective To analyze the laws and characteristics of the adverse drug reaction (ADR) of traditional Chinese medicine injection in Chongqing Yongchuan District Hospital, and to provide a reference for rational drug use of traditional Chinese medicine injection. Methods A retrospective study was conducted on the ADR reports. The related information was recorded. Then the data according to related guidelines and documents were analyzed. Results A total of 180 ADR reports were included according to inclusion criteria. The ratio of males to females is close, and most patients were above 70 years old, accounting for 24.44%. ADR mainly occurred in 10-30 min after medication, accounting for 35.00%. The main symptoms of adverse reactions were the skin and accessories (97 cases, 53.89%), followed by systemic symptoms (32 cases, 17.78%). There were 32 kinds of traditional Chinese medicine injections, and the top three traditional Chinese medicine injections causing ADR were Xuesaitong for injection, Shuxuening Injection, and Danshen Chuanxiongqin Injection. Conclusion ADR monitoring of traditional Chinese medicine injection should be strengthened to promote the safety of drug use.