金钱草颗粒联合熊去氧胆酸治疗胆囊结石的临床研究

目的探讨金钱草颗粒联合熊去氧胆酸片治疗胆囊结石的临床疗效。方法选取2018年6月—2019年10月濮阳市油田总医院收治的86例胆囊结石患者作为研究对象,所有患者根据随机数字表法分为对照组和治疗组,每组各43例。对照组口服熊去氧胆酸片,0.25 g/次,2次/d。治疗组在对照组治疗的基础上温水冲服金钱草颗粒,10.0 g/次,3次/d。两组连续治疗2个月。观察两组的临床疗效,比较两组的胆囊症状、血清因子水平、疼痛程度。结果治疗后,对照组和治疗组的总有效率分别为76.74%、93.02%,两组比较差异有统计学意义(P0.05)。治疗后,两组的结石直径、结石数目明显减小,胆囊排空率明显升高,同组治疗前后比较差异有统计学意义(P0.05);且治疗后治疗组的结石直径、结石数目比对照组小,胆囊排空率比对照组高,两组差异有统计学意义(P0.05)。治疗后,两组的血管活性肠肽(VIP)、调宁蛋白(Cap)水平明显降低,胆囊收缩素受体(CCK-A)水平明显升高,同组治疗前后比较差异有统计学意义(P0.05);且治疗后治疗组的VIP、Cap水平比对照组低,CCK-A水平比对照组高,两组差异有统计学意义(P0.05)。治疗后,两组的VAS评分明显降低,同组治疗前后比较差异有统计学意义(P0.05);且治疗组VAS评分明显低于对照组,两组差异有统计学意义(P0.05)。结论金钱草颗粒联合熊去氧胆酸片治疗胆囊结石具有较好的临床疗效,能改善胆囊症状,调节相关蛋白水平,降低疼痛程度,具有一定的临床推广应用价值。

Clinical study on Jinqiancao Granules combined with ursodeoxycholic acid in treatment of gallstone

Objective To explore the clinical effect of Jinqiancao Granules combined with Ursodeoxycholic Acid Tablets in treatment of gallstone. Methods Patients (86 cases) with gallstone in Puyang Oilfield General Hospital from June 2018 to August 2019 were randomly divided into control and treatment groups, and each group had 43 cases. Patients in the control group were po administered with Ursodeoxycholic Acid Tablets, 0.25 g/time, twice daily. Patients in the treatment group were po administered with Jinqiancao Granules on the basis of the control group, 10.0 g/time, three times daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacies were evaluated, and gallbladder symptoms, serum factors levels, and VAS scores in two groups were compared.. Results After treatment, the clinical efficacies in the control and treatment groups were 76.74% and 93.02%, respectively, and there was difference between two groups (P<0.05). After treatment, the diameter and number of gallstones in two groups were significantly decreased, but the gallbladder emptying rates in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the gallbladder symptom indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of VIP and Cap in two groups were significantly decreased, but the levels of CCK-A in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the serum factors levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the VAS scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the VAS scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Jinqiancao Granules combined with Ursodeoxycholic Acid Tablets has clinical curative effect in treatment of gallstone, can improve gallbladder symptoms, regulate the level of related proteins, and reduce the degree of pain, which has a certain clinical application value.