Phosphorylation ofHelicobacter pylori CagA in patients with gastric ulcer and gastritis |
| |
| Authors: | Ken-Sheng Cheng Min-Chi Lu Hui-Ling Tang Fu-Tsan Chou |
| |
| Affiliation: | (1) Department of Internal Medicine Division of Gastroenterology, China Medical College Hospital, Yu-Der Road 2, 40421 Taichung, Taiwan R.O.C. |
| |
| Abstract: | The effects ofHelicobacter pylori infection are strongly associated with chronic gastritis, gastric and duodenal ulcer, gastric cancer, and MALT lymphoma. The microorganism has been classified as a type I carcinogen by the World Health Organization. Varying clinical results fromH. pylori infection are believed due, in part, to differences in virulence among species. Thecag pathogenicity island is a complex of virulent genes and a coding region for the type IV phosphorylated secretion system. Through this system, many virulent gene products or proteins are phosphorylated into the host cells. This study demonstrated the positiveCagA- phosphorylation effect ofH. pylori in patients with chronic gastritis and benign gastric ulcer and revealed significantly different rates ofCagA phosphorylation between these two diseases (P < .05). |
| |
| Keywords: | type IV phosphorylation pathogenicity island gastritis gastric ulcer |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
