Lymphocyte immunophenotype reference ranges in healthy Indian adults: implications for management of HIV/AIDS in India |
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Authors: | Amatya Ritu Vajpayee Madhu Kaushik Shweta Kanswal Sunita Pandey R M Seth Pradeep |
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Institution: | Department of Microbiology, All India Institute of Medical Sciences, 110029 New Delhi, India. |
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Abstract: | With the advent and application of standard and sensitive flow cytometry methods, it became essential to establish reference intervals in healthy individuals to demarcate between health and disease. A reference range of lymphocyte populations for normal individuals is important in the diagnosis and prognosis of immunodeficiency diseases like AIDS. We tried to accomplish this by studying the values for T lymphocyte subsets for 200 healthy North Indian adults between 18 and 55 years. We obtained the following reference ranges for various T lymphocyte subsets: CD4 count (304-1864 cells/microl with the median of 666 cells/microl), CD4% (17.5-50.6% with the median of 35%), CD8% (14-53% with the median of 32.3%), CD3% (43-89% with the median of 70.5%), and CD4/CD8 ratio (0.04-3.5 with the median of 1.04). Significant variations were observed for normal reference intervals for T lymphocyte subsets according to the race, ethnic origin, age group, and gender. |
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Keywords: | HIV Reference range CD4 count India |
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