| 高效液相色谱电化学法测定血间甲肾上腺素类物质方法的建立及临床应用 |
| |
| 引用本文： | 姜蕾,王卫庆,张军妮,戴蒙,苏颋为,宁光. 高效液相色谱电化学法测定血间甲肾上腺素类物质方法的建立及临床应用[J]. 中华内分泌代谢杂志, 2004, 20(6): 561-563 |
| |
| 作者姓名： | 姜蕾 王卫庆 张军妮 戴蒙 苏颋为 宁光 |
| |
| 作者单位： | 200025,上海第二医科大学附属瑞金医院内分泌代谢病科,上海市内分泌代谢病临床中心,上海市内分泌代谢病研究所 |
| |
| 基金项目： | 上海市科委课题 (341 1 981 8) |
| |
| 摘 要： | 嗜铬细胞瘤是以儿茶酚胺大量分泌为特征的肿瘤。研究发现 ,与儿茶酚胺等测定指标相比较 ,间甲肾上腺素类物质 (MNs)具有更高的敏感性和特异性。本研究用高效液相色谱电化学分析法建立了血MNs的测定方法 ,并对 40名健康人及 2 6名经病理证实的嗜铬细胞瘤患者进行了血MNs的测定 ,MNs水平在嗜铬细胞瘤患者中与临床、病理符合率为 10 0 %。
|
| 关 键 词： | 间甲肾上腺素类 色谱法 高压液相 电化学 嗜铬细胞瘤 |
| 修稿时间： | 2004-07-07 |
Establishment of assay for plasma metanephrines by HPLC-ED and its clinical application |
| |
| JIANG Lei,WANG Wei-qing,ZHANG Jun-ni,DAI Mong,SU Ting-wei,NING Guang. Establishment of assay for plasma metanephrines by HPLC-ED and its clinical application[J]. Chinese Journal of Endocrinology and Metabolism, 2004, 20(6): 561-563 |
| |
| Authors: | JIANG Lei WANG Wei-qing ZHANG Jun-ni DAI Mong SU Ting-wei NING Guang |
| |
| Affiliation: | JIANG Lei,WANG Wei-qing,ZHANG Jun-ni,DAI Mong,SU Ting-wei,NING Guang. Department of Endocrine and Metabolic Diseases,Shanghai Clinical Center for Endocrine and Metabolic Diseases,Shanghai Institute of Endocrine and Metabolic Diseases,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025 Corresponding author: NING Guang,Email: guangning@medmail.com.cn |
| |
| Abstract: | Pheochromocytomas is the tumor characterized by excessive production of catecholamines. Some studies showed that for the diagnosis of pheochromocytomas, measurement of metanephrines is more sensitive and more specific than that of catecholamines. In this study, plasma MNs were detected by HPLC-ED and the normal range of their plasma levels were determined in 40 healthy subjects. Moreover, the positive detection rate of plasma MNs in 26 pheochromocytoma patients is completely accordant with their pathological diagnosis. |
| |
| Keywords: | Metanephrines Chromatography high pressure liquid Electrochemistry Pheochromocytoma |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
