Overexpression of the oncogenic kinase Pim-1 leads to genomic instability |
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Authors: | Roh Meejeon Gary Bernard Song Chisu Said-Al-Naief Nasser Tousson Albert Kraft Andrew Eltoum Isam-Eldin Abdulkadir Sarki A |
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Institution: | Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294-0007, USA. |
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Abstract: | Aneuploidy and chromosomal aberrations are hallmarks of most human epithelial malignancies. Here we show that overexpression of the oncogenic kinase Pim-1 in human prostate epithelial cells induces genomic instability by subverting the mitotic spindle checkpoint. Cells overexpressing Pim-1 have a defect in the mitotic spindle checkpoint, abnormal mitotic spindles, centrosome amplification, and chromosome missegregation. Polyploidy and aneuploidy ensue due to a delay in completing cytokinesis. These results define a novel role for elevated Pim-1 expression in promoting genomic instability in human prostate tumors. |
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