Effect of synthetic dermorphin analogues on tissue homeostasis in the myocardium of newborn albino rats |
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| Authors: | S. Yu. Kriganovskaya O. A. Lebed’ko E. N. Sazonova S. S. Timoshin L. E. Molokanova |
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| Affiliation: | (1) Central Research Laboratory, Far-Eastern State Medical University, Russia;(2) Institute of Maternity and Child Welfare, Khabarovsk Branch, Far-Eastern Research Center for Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Russia |
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| Abstract: | DNA synthesis and state of the nucleolar apparatus in myocardial cells of newborn albino rats receiving intraperitoneal injection of sedatin, a synthetic dermorphin analogue, were studied by means of autoradiography and silver impregnation. Labeling intensity significantly increased, while the number of nucleoli in nuclei decreased. Chemiluminescence study showed that the concentration of reactive oxygen metabolites significantly decreased in the myocardium of treated animals after sedatin administration. Non-arginine analogue of sedatin had little effect on tissue homeostasis in the myocardium. __________ Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 10, pp. 413–416, October, 2007 |
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| Keywords: | opioid peptides myocardium proliferative activity nucleolar apparatus reactive oxygen metabolites |
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