| 浙贝母生物碱体外透皮吸收的实验研究 |
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| 引用本文： | 林晓,彭新生.浙贝母生物碱体外透皮吸收的实验研究[J].亚太传统医药,2011,7(4):15-18. |
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| 作者姓名： | 林晓 彭新生 |
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| 作者单位： | 广东医学院,药学实验室,广东,东莞,523808 |
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| 摘 要： | 目的:研究浙贝母中主要成分生物碱的透皮吸收特性,考察不同浓度溶剂及常用渗透促进剂Azone对其透皮特性的影响。方法:采用药物透皮扩散试验仪进行体外扩散实验,选择离体大鼠背部皮肤为渗透屏障,用UV检测法测定样品中生物碱的含量。结果:浙贝母中主要生物碱的70%乙醇溶液、95%乙醇溶液均可透过大鼠背部皮肤,其差异有统计学意义(P<0.01),但渗透系数较小;Azone对其无显著促渗透作用(P>0.05)。结论:此法将为其经皮给药制剂研究提供可靠实验依据。
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| 关 键 词： | 浙贝母 生物碱 透皮吸收 氮酮 |
Experimental Study on percutaneous absorption of main alkaloids in Fritillaria Thunbergiin vitr |
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| Lin Xiao,Peng Xinsheng.Experimental Study on percutaneous absorption of main alkaloids in Fritillaria Thunbergiin vitr[J].Asia-Pacific Traditional Medicine,2011,7(4):15-18. |
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| Authors: | Lin Xiao Peng Xinsheng |
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| Institution: | Lin Xiao,Peng Xinsheng(Laboratory of pHarmacy,Guangdong Medical College,Guangdong 523808,China) |
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| Abstract: | Objective：To study percutaneous absorption of main alkaloids in Fritillaria Thunbergii in vitro and the effects of some commom enhancer Azone and solvent in different concent rations value on it.Methods：Drμg permeation tests were performed throμgh excised rat skin in the diffusion cell and main alkaloids concentration in samples was determined by UV.Results：Main alkaloids could penetrate throμgh excised rat skin with lower permeability coefficient（P0.01）;2%Azone has not markedly promotive effect on transdermal penetration of main alkaloids.Conclusion：The research will p rovide experimental data for skin administration of Chinese medicine containing main alkaloids in Fritillaria Thunbergii. |
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| Keywords: | Fritillaria Thunbergii Alkaloids Percutaneous Absorption Azone |
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