Substance Use and its Association with Psychiatric Symptoms in Perinatally HIV-infected and HIV-Affected Adolescents |
| |
Authors: | Paige L Williams Erin Leister Miriam Chernoff Sharon Nachman Edward Morse Vinnie Di Poalo Kenneth D Gadow |
| |
Institution: | (1) Center for Biostatistics in AIDS Research, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA;(2) Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA, USA;(3) Department of Pediatrics, Stony Brook University, Stony Brook, NY, USA;(4) Tulane University Health Sciences Center, New Orleans, LA, USA;(5) Robert Wood Johnson University Hospital, Hazlet, NJ, USA;(6) Department of Psychiatry and Behavioral Science, Stony Brook University, Stony Brook, NY, USA |
| |
Abstract: | Drug use in combination with psychiatric illness may lead to unsafe sexual risk behavior and increased risk for secondary
HIV transmission among adolescents with HIV infection. We compared the prevalence of substance use for perinatally HIV-infected
youth to uninfected adolescents living in families affected by HIV infection, and evaluated the association of psychiatric
symptoms with risk of substance use. Among 299 adolescents (196 HIV+, 103 HIV−) aged 12–18 years enrolled in IMPAACT P1055,
a multisite US cohort study, 14% reported substance use at enrollment (HIV+: 13%, HIV−: 16%). In adjusted logistic regression
models, adolescents had significantly higher odds of substance use if they met symptom criteria for ADHD adjusted odds ratio
(aOR) = 2.7, Wald χ2 = 5.18, P = 0.02], major depression or dysthymia (aOR = 4.0, Wald χ2 = 7.36, P = 0.01), oppositional defiant disorder (aOR = 4.8, Wald χ2 = 12.7, P = 0.001), or conduct disorder (aOR = 15.4, Wald χ2 = 28.12, P = 0.001). Among HIV-infected youth, those with lower CD4 lymphocyte percentage (CD4% < 25%) had significantly increased risk
of substance use (aOR = 2.7, Wald χ2 = 4.79, P = 0.03). However, there was no overall association of substance use with HIV infection status, and the association between
psychiatric symptoms and substance use did not differ by HIV status. Programs to prevent substance use should target both
HIV-infected and uninfected adolescents living in families affected by HIV infection, particularly those with psychiatric
symptoms. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|