| 高渗盐液、右旋糖酐、山莨菪硷联合抢救兔失血性休克 |
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| 引用本文： | 方玉荣,孔桂英,罗正曜,詹群珊,刘士坤.高渗盐液、右旋糖酐、山莨菪硷联合抢救兔失血性休克[J].中南大学学报(医学版),1990(3). |
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| 作者姓名： | 方玉荣 孔桂英 罗正曜 詹群珊 刘士坤 |
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| 作者单位： | 湖南医科大学病理生理学教研室进修班，湖南医科大学病理生理学教研室，湖南医科大学病理生理学教研室，湖南医科大学病理生理学教研室，湖南医科大学病理生理学教研室 教师 |
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| 摘 要： | 合并使用高渗盐液、右旋糖酐与山莨菪硷治疗家兔实验性严重失血性休克。结果显示:高渗盐液加右旋糖酐治疗组,平均动脉压、左室内压、左室内压变化速率、中心静脉压等血流动力学指标的恢复,显著优于等渗盐液治疗组;高渗盐液、右旋糖酐与山莨菪硷(5mg/kg)联用组,动脉血压回升后维持时间、中心静脉压升高的程度优于高渗盐液加右旋糖酐组。进一步证实联用高渗液与山莨菪硷可短时提高疗效,为抢救休克赢得时间。
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| 关 键 词： | 休克 出血性 高张液 右旋糖酐 山莨菪硷 药物疗法 治疗应用 兔 |
HYPERTONIC SALINE, DEXTRAN SOLUTION AND ANISODAMINE IN RESUSITATION OF SEVERE HEMORRHAGIC SHOCK |
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| Fang Yurong Kong Guiying Luo Zhengyao Zhan Qunshan Liu Shikun.HYPERTONIC SALINE, DEXTRAN SOLUTION AND ANISODAMINE IN RESUSITATION OF SEVERE HEMORRHAGIC SHOCK[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),1990(3). |
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| Authors: | Fang Yurong Kong Guiying Luo Zhengyao Zhan Qunshan Liu Shikun |
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| Institution: | Fang Yurong Kong Guiying Luo Zhengyao Zhan Qunshan Liu ShikunDepartment of Patho physiology,Hunan Medical University |
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| Abstract: | Hemorrhagic shock was induced in rabbits by controlled arterial bleeding, to reduce and maintain mean arterial blood pressure at 5. 3 kPa for 30 min. The rabbits were then given 4ml/kg i. v. 1) isotonic NaCl (IS), 2) 7.5 NaC1/6% dextran 40 ( HS/DX), 3) 7.5% NaC1/6% dextran 40 + aniso-damine 5mg/kg ( HS/DX + 654-2). The results showed that MAP, LVP, dp/dt max and CVP were better improved in HS/DX and HS/DX+654-2 groups than in IS group, the MAP, CVP more effective in HS/DX + 654-2 group than in HS/DX group. The MDA/SOD ratio increased in IS and HS/DX group, but there was no significant change in HS/DX+654-2 group. Consequently, the oxygen-free radicals were produced in hemorrhagic shock. Anisodamine may have the effect against oxygen-free radicals directly or indirectly. |
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| Keywords: | shock hemorragic hypertonic solution dextran anisodamine drug therapy therapeutic use rabbits |
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