流行性出血热危险因素的病例对照研究

用病例对照研究方法探索建德县罹患流行性出血热(EHF)的危险因素。经临床诊断和血清学证实的97例EHF病例,按年龄、性别和住同一医院与其他疾病病人作1:1配对调查。条件logistic回归模型分析,发现村中曾有EHF史、外出他县、野宿和直接接触鼠类四个因素是罹患EHF的危险因素,其相对危险度分别为35.67、11.94、18.18和7.36。病例家属隐性感染率(4.95％)与对照家属隐性感染率(5.12％)相似;病例与对照家中捕获的鼠类及其EHF抗体、抗原阳性率无显著性差异。

CASE CONTROL STUDY ON RISK FACTORS OF EPIDEMIC HEMORRHAGIC FEVER

A case control study was conducted in Jiende county to study risk factors of epidemic hemorrhagic fever (EHF). 97 cases, which had been clinically diagnosed as EHF and confirmed by IFA, were matched with patients with other diseases (1:1), according to age and sex in the Same hospital. Conditional logistic regression analysis showed that occurrence of previous EHF infection in the village, travelling to other counties, lodging in field camps and direct contact with rodenta were risk factors of EHF infection and their OEs were 35.67, 11.94, 18.18 and 7.36 respectively. The rate of subclinical infection in family members of the index case (4.95%) was similar to that in family members of the controls (5.12%). Differences between the incidences of EHF antibody and antigen in rodenta captured in case houses and those in rodents captured in control houses were also not significant, suggesting that the higher risk in the case group may depend on human behavior.