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| 香烟烟雾对大鼠血脂和脂质过氧化的影响 | |
| 引用本文： | 罗建军,曾明,尹晓晨,关岚,郭颂,潘宏磊,李亚琪,罗俊,彭锋.香烟烟雾对大鼠血脂和脂质过氧化的影响[J].实用预防医学,2008,15(5):1345-1347. |
| 作者姓名： | 罗建军 曾明 尹晓晨 关岚 郭颂 潘宏磊 李亚琪 罗俊 彭锋 |
| 作者单位： | 1. 中南大学公共卫生学院,湖南,长沙,410078 2. 中南大学公共卫生学院毒理学系 3. 中南大学湘雅医学院 |
| 基金项目： | 中南大学校科研和教改项目 |
| 摘 要： | 目的通过环境香烟烟雾(ETS)染毒模型,观察香烟烟雾对大鼠血脂水平及体内脂质过氧化的影响。方法正常8周龄SD大鼠20只,随机分为二组:吸烟组(10只)和对照组(10只),吸烟组大鼠每天染毒2h。比较测定大鼠血脂水平和血清、肝脏和肺脏的MDA含量和SOD活性。结果吸烟组大鼠连续染毒8周后,血清TG明显高于对照组(P<0.05)、HDL-C明显低于对照组(P<0.05);血清和肝、肺组织中MDA含量明显升高(P<0.05)、而SOD活力明显降低(P<0.05)。结论环境香烟烟雾可引起大鼠血脂紊乱,并造成血液、肝脏和肺脏的脂质过氧化损伤。 |
| 关 键 词： | 环境香烟烟雾 大鼠 血脂 脂质过氧化 |
Effects of Environmental Tobacco Smoking on Serum Lipid and Lipid Peroxidation in Rats |
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| LUO Jian-jun,ZENG Ming,YIN Xiao-chen,et al..Effects of Environmental Tobacco Smoking on Serum Lipid and Lipid Peroxidation in Rats[J].Practical Preventive Medicine,2008,15(5):1345-1347. | |
| Authors: | LUO Jian-jun ZENG Ming YIN Xiao-chen |
| Abstract: | Objective To study effects of environmental tobacco smoking on serum lipids and lipid peroxidation in rats.Methods Twenty healthy 8-week old SD rats were randomly divided into following 2 groups:smoking group(n=10) and control group(n=10).The rats were exposed to ETS for 2 every day.The contents of serum lipids,MDA concentration,and the activity of SOD in serum,lung,and liver were measured respectively.Results After being exposed to ETS for 8 weeks,the levels of TG in smoking group were significantly higher than those of control group.The levels of HDL-C in smoking group were significantly lower than those of control group(P<0.05).The content of MDA in serum,lung,and liver of exposed rats was significantly higher than that of controls(P<0.05),while SOD activity was lower in serum,lung and liver of exposed rats(P<0.05).Conclusion ETS leads to dyslipidemia,and induces lipid peroxidation damages in blood,lung and liver of exposed rats. |
| Keywords: | Environmental tobacco smoking Rat Serum lipids Lipid peroxidation |
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