| 抗肿瘤的苯并二吡咯类抗生素-单克隆抗体结合物 |
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| 引用本文： | 顾月,顾觉奋. 抗肿瘤的苯并二吡咯类抗生素-单克隆抗体结合物[J]. 药学进展, 2008, 32(4): 152-157 |
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| 作者姓名： | 顾月 顾觉奋 |
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| 作者单位： | 中国药科大学生命科学与技术学院,江苏,南京,210009 |
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| 摘 要： | 介绍有关抗肿瘤的苯并二吡咯类抗生素衍生物一单克隆抗体结合物的研究情况。苯并-二吡咯类抗生素有极强的细胞毒性，抗肿瘤活性强；而单克隆抗体具有高度的抗原特异性。通过适当的方法，将苯并二吡咯类抗生素与某些肿瘤细胞的单克隆抗体结合，制成的苯并二吡咯类抗生素一单克隆抗体结合物是极具临床应用潜力的抗肿瘤药物。
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| 关 键 词： | 苯并二吡咯类化合物 半合成抗生素 单克隆抗体 结合物 抗肿瘤药 |
| 文章编号： | 1001-5094(2008)04-0152-06 |
| 修稿时间： | 2008-02-25 |
Benzodipyrrole Antibiotic-Monoclonal Antibody Conjugates: A Class of Antitumor Drugs |
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| GU Yue,GU Jue-fen. Benzodipyrrole Antibiotic-Monoclonal Antibody Conjugates: A Class of Antitumor Drugs[J]. Progress in Pharmaceutical Sciences, 2008, 32(4): 152-157 |
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| Authors: | GU Yue GU Jue-fen |
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| Affiliation: | (School of Life Science and Technology, China Pharmaceutical University, Nanfing 210009, China) |
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| Abstract: | Benzodipyrrole antibiotics is a class of compounds with cell-toxicity and has a high antitumor activity. Monoclonal antibody （McAb） was highly specific to its antigen and could be made for specific molecular target sites. Benzodipyrrole antibiotic-McAb conjugates prepared by suitable techniques showed a great potential therapy on tumor. The status of development of benzodipyrrole antibiotic-McAb conjugates was summarized in this paper. |
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| Keywords: | Benzodipyrrole Sino-antibiotics Monoclonal antibody Conjugate Antitumor |
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